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Journal article
Genetic Contributions to Maternal and Neonatal Vitamin D Levels
Genetics (Austin), v 214(4), pp 1091-1102
Apr 2020
PMID: 32047095
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Vitamin D is essential for several physiological functions and biological processes. Increasing levels of maternal vitamin D are required throughout pregnancy as a unique source of vitamin D for the fetus, and consequently maternal vitamin D deficiency may result in several adverse outcomes in newborns. However, the genetic regulation of vitamin D in pregnancy and at birth is not yet well understood. We performed genome-wide association studies of maternal midgestational serum-derived and neonatal blood-spot-derived total 25-hydroxyvitamin D from a case-control study of autism spectrum disorder (ASD). We identified one fetal locus (rs4588) significantly associated with neonatal vitamin D levels in the
gene, encoding the binding protein for the transport and function of vitamin D. We also found suggestive cross-associated loci for neonatal and maternal vitamin D near immune genes, such as
and
We found no interactions with ASD. However, when including a set of cases with intellectual disability but not ASD (
= 179), we observed a suggestive interaction between decreased levels of neonatal vitamin D and a specific maternal genotype near the
gene. Our results suggest that genetic variation influences total vitamin D levels during pregnancy and at birth via proteins in the vitamin D pathway, but also potentially via distinct mechanisms involving loci with known roles in immune function that might be involved in vitamin D pathophysiology in pregnancy.
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Details
- Title
- Genetic Contributions to Maternal and Neonatal Vitamin D Levels
- Creators
- Michela Traglia - University of California, San FranciscoGayle C Windham - California Department of Public HealthMichelle Pearl - California Department of Public HealthVictor Poon - Sequoia FoundationDarryl Eyles - University of QueenslandKaren L Jones - University of California, DavisKristen Lyall - Drexel UniversityMartin Kharrazi - California Department of Public HealthLisa A Croen - Kaiser PermanenteLauren A Weiss - University of California, San Francisco
- Publication Details
- Genetics (Austin), v 214(4), pp 1091-1102
- Grant note
- R01 HD079533 / NICHD NIH HHS R01 ES016669 / NIEHS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Computing and Informatics; A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000527690300023
- Scopus ID
- 2-s2.0-85085390379
- Other Identifier
- 991019168010104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Genetics & Heredity