Journal article
Geographic Patterns of Autism Spectrum Disorder Among Children of Participants in Nurses' Health Study II
American journal of epidemiology, v 186(7), pp 834-842
01 Oct 2017
PMID: 28525627
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Data indicate that the prevalence of autism spectrum disorder (ASD) may be increasing and that it varies geographically. We investigated associations between residential location and ASD in the children of Nurses' Health Study II (United States) participants in order to generate hypotheses about social and environmental factors related to etiology or diagnosis. Analyses included data on 13,507 children born during 1989-1999 (486 with ASD). We explored relationships between ASD and residential location both at birth and at age 6 years (i.e., closer to average age at diagnosis). Generalized additive models were used to predict ASD odds across the United States. Children born in New England were 50% more likely to be diagnosed with ASD compared with children born elsewhere in the United States. Patterns were not explained by geographic variation in maternal age, birth year, child's sex, community income, or prenatal exposure to hazardous air pollutants, indicating that spatial variation is not attributable to these factors. Using the residential address at age 6 years produced similar results; however, areas of significantly decreased ASD odds were observed in the Southeast, where children were half as likely to have ASD. These results may indicate that diagnostic factors are driving spatial patterns; however, we cannot rule out the possibility that other environmental factors are influencing distributions.
Metrics
Details
- Title
- Geographic Patterns of Autism Spectrum Disorder Among Children of Participants in Nurses' Health Study II
- Creators
- Kate Hoffman - Duke UniversityMarc G. Weisskopf - Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USAAndrea L. Roberts - Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA USARaanan Raz - Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USAJaime E. Hart - Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USAKristen Lyall - Drexel UniversityElin M. Hoffman - Appalachian State UniversityFrancine Laden - Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USAVeronica M. Vieira - Univ Calif Irvine, Coll Hlth Sci, Program Publ Hlth, Irvine, CA USA
- Publication Details
- American journal of epidemiology, v 186(7), pp 834-842
- Publisher
- Oxford Univ Press
- Number of pages
- 9
- Grant note
- UM1CA176726 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) P42ES007381; P30ES000002 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) UM1 CA176726 / National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) P42 ES007381; P30 ES000002 / National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000412124500011
- Scopus ID
- 2-s2.0-85030644002
- Other Identifier
- 991020100211704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health