Journal article
Hybrid Continuous-Flow Total Artificial Heart
Artificial organs, v 42(5), pp 500-509
May 2018
PMID: 29349805
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Clinical studies using total artificial hearts (TAHs) have demonstrated that pediatric and adult patients derive quality-of-life benefits from this form of therapy. Two clinically-approved TAHs and other pumps under development, however, have design challenges and limitations, including thromboembolic events, neurologic impairment, infection risk due to large size and percutaneous drivelines, and lack of ambulation, to name a few. To address these limitations, we are developing a hybrid-design, continuous-flow, implantable or extracorporeal, magnetically-levitated TAH for pediatric and adult patients with heart failure. This TAH has only two moving parts: an axial impeller for the pulmonary circulation and a centrifugal impeller for the systemic circulation. This device will utilize the latest generation of magnetic bearing technology. Initial geometries were established using pump design equations, and computational modeling provided insight into pump performance. The designs were the basis for prototype manufacturing and hydraulic testing. The study results demonstrate that the TAH is capable of delivering target blood flow rates of 1-6.5 L/min with pressure rises of 1-92 mm Hg for the pulmonary circulation and 24-150 mm Hg for the systemic circulation at 1500-10 000 rpm. This initial design of the TAH was successful and serves as the foundation to continue its development as a novel, more compact, nonthrombogenic, and effective therapeutic alternative for infants, children, adolescents, and adults with heart failure.
Metrics
Details
- Title
- Hybrid Continuous-Flow Total Artificial Heart
- Creators
- Carson Fox - Drexel UniversitySteven Chopski - Drexel UniversityNohra Murad - Drexel UniversityPaul Allaire - Rotor Bearing Solutions International, Charlottesville, VA, USA.Robert Mentzer, Jr - Cedars-Sinai Heart Institute, Los Angeles, CA, USAJoseph Rossano - Children's Hospital of PhiladelphiaFrancisco Arabia - Cedars-Sinai Medical CenterAmy Throckmorton - Drexel University
- Publication Details
- Artificial organs, v 42(5), pp 500-509
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000433563800008
- Scopus ID
- 2-s2.0-85040722218
- Other Identifier
- 991019169683404721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Transplantation