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Journal article
Identification of fucosylated Fetuin-A as a potential biomarker for cholangiocarcinoma
Proteomics. Clinical applications, v 11(9-10), pp 1600141-n/a
Sep 2017
PMID: 28561948
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cholangiocarcinoma (CCA) is a malignancy of the bile ducts. The purpose of this discovery study was to identify effective serum markers for surveillance of cholangiocarcinoma.
Using a glycomic method, patients with CCA were determined to have increased levels of alpha-1,3 and alpha-1,6 linked fucosylated glycan. Proteomic analysis of the serum fucosylated proteome identified proteins such as alpha-2-macroglobulin, kininogen, hemopexin, fetuin-A, alpha-1 anti-trypsin, and ceruloplasmin as being hyperfucosylated in HCC. The levels of these glycoproteins in 109 patients with CCA, primary sclerosing cholangitis (PSC), and control patients were compared to the performance of CA-19-9, the current "gold standard" assay for cholangiocarcinoma.
Fucosylated Fetuin-A (fc-Fetuin-A) had the best ability to differentiate CCA from PSC, with an AUROC of 0.812 or 0.8665 at differentiating CCA from those with PSC or other liver disease. CA-19-9 had poor ability to differentiate PSC from cholangiocarcinoma (AUROC of 0.625).
Using glycomic and proteomic methods we identified a set of proteins that contain altered glycan in the sera of those with CCA. One of these proteins, fucosylated Fetuin-A may have value in the surveillance of people at risk for the development of cholangiocarcinoma.
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Details
- Title
- Identification of fucosylated Fetuin-A as a potential biomarker for cholangiocarcinoma
- Creators
- Lucy Betesh - Medical University of South CarolinaMary Ann Comunale - Medical University of South CarolinaMengjun Wang - Medical University of South CarolinaHongyan Liang - Medical University of South CarolinaJulie Hafner - Baruch S. Blumberg InstituteAykan Karabudak - Baruch S. Blumberg InstituteNasra H Giama - Mayo Clinic in ArizonaCatherine D Moser - Mayo Clinic in ArizonaEiji Miyoshi - The University of OsakaLewis R Roberts - Mayo Clinic in ArizonaTimothy M Block - Medical University of South CarolinaAnand Mehta - Medical University of South Carolina
- Publication Details
- Proteomics. Clinical applications, v 11(9-10), pp 1600141-n/a
- Publisher
- Wiley
- Grant note
- U01 CA168856 / NCI NIH HHS R01 CA120206 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Medicine (Graduate)
- Web of Science ID
- WOS:000411488300001
- Scopus ID
- 2-s2.0-85022338988
- Other Identifier
- 991020537773904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemical Research Methods
- Biochemistry & Molecular Biology