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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Inattention and hyperactivity in association with autism spectrum disorders in the CHARGE study
Research in autism spectrum disorders, v 35, pp 1-12
Mar 2017
PMID: 29276530
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•This is the largest population-based study of ADHD-related symptoms in young children with ASD in association with cognitive and behavioral scores.•Our results confirm the high prevalence of attention deficits in children aged 2–5 with ASD, relative to children with typical development or developmental delay.•We found significant associations between higher levels of attention deficits in children with ASD and lower scores on cognitive and behavioral assessments.•These results suggest ADHD symptoms in young children with ASD play an important role in impacting other areas of functioning.
Attention deficits in young children with autism spectrum disorder (ASD) are not well understood. This study sought to determine: 1) the prevalence of ADHD symptoms in young children with ASD, typical development (TD), and developmental delay (DD) and 2) the association between ADHD symptoms and cognitive and behavioral functioning in children with ASD.
ADHD symptoms, defined according to Aberrant Behavior Checklist (ABC) hyperactivity subscale scores, were compared across children aged 2–5 from a large case-control study with ASD (n=548), TD (n=423), and DD (n=180). Inattention and hyperactivity items within this subscale were also explored. Within the ASD group, linear and logistic regression were used to examine how ADHD symptoms were associated with cognition as assessed by the Mullen Scales of Early Learning and adaptive functioning as assessed by the Vineland Adaptive Behavior Scales.
Mean hyperactivity subscale scores were lowest in children with TD (mean=3.19), higher in children with DD (12.3), and highest in children with ASD (18.2; between-group p<0.001). Among children with ASD, significant associations were observed with higher ADHD symptoms and poorer adaptive and cognitive functioning (adjusted beta for hyperactivity score in association with: Vineland composite=−5.63, p=0.0005; Mullen visual reception scale=−2.94, p=0.02; for the highest vs. lowest quartile of hyperactivity score, odds of lowest quintile of these scores was approximately doubled). Exploratory analyses highlighted associations with inattention-related items specifically.
These results suggest ADHD symptoms may play a key role in the functioning of young children with ASD.
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Details
- Title
- Inattention and hyperactivity in association with autism spectrum disorders in the CHARGE study
- Creators
- Kristen Lyall - Univeristy of California, Department of Public Health Sciences, Davis CA 95616.Julie B. Schweitzer - University of California, DavisRebecca J. Schmidt - Univeristy of California, Department of Public Health Sciences, Davis CA 95616.Irva Hertz-Picciotto - Univeristy of California, Department of Public Health Sciences, Davis, CA 95616, United StatesMarjorie Solomon - University of California, Davis
- Publication Details
- Research in autism spectrum disorders, v 35, pp 1-12
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000394199800001
- Scopus ID
- 2-s2.0-85006874620
- Other Identifier
- 991020100190304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Education, Special
- Psychiatry
- Psychology, Developmental
- Rehabilitation