Journal article
Increased Levels of Galactose-Deficient Anti-Gal Immunoglobulin G in the Sera of Hepatitis C Virus-Infected Individuals with Fibrosis and Cirrhosis
Journal of virology, v 82(3), pp 1259-1270
Feb 2008
PMID: 18045939
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hepatitis B and C viruses are major causative agents of liver fibrosis, cirrhosis, and liver cancer. Using comparative glycoproteomics, we identified a glycoprotein that is altered both in amount and in glycosylation as a function of liver fibrosis and cirrhosis. Specifically, this altered glycoprotein is an immunoglobulin G (IgG) molecule reactive to the heterophilic alpha-Gal epitope [Galα-1-3Galβ1-(3)4GlcNAc-R]. While similar changes in glycosylation have been observed in several autoimmune diseases, the specific immunoglobulins and their antigen recognition profiles were not determined. Thus, we provide the first report identifying the specific antigenic recognition profile of an immunoglobulin molecule containing altered glycosylation as a function of liver disease. This change in glycosylation allowed increased reactivity with several fucose binding lectins and permitted the development of a plate-based assay to measure this change. Increased lectin reactivity was observed in 100% of the more than 200 individuals with stage III or greater fibrosis and appeared to be correlated with the degree of fibrosis. The reason for the alteration in the glycosylation of anti-Gal IgG is currently unclear but may be related to the natural history of the disease and may be useful in the noninvasive detection of fibrosis and cirrhosis.
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Details
- Title
- Increased Levels of Galactose-Deficient Anti-Gal Immunoglobulin G in the Sera of Hepatitis C Virus-Infected Individuals with Fibrosis and Cirrhosis
- Creators
- Anand S Mehta - Drexel University College of Medicine and Department of Microbiology and Immunology and Drexel Institute for Biotechnology and Virology, 700 East Butler Avenue, Doylestown, Pennsylvania 18901Ronald E Long - Drexel University College of Medicine and Department of Microbiology and Immunology and Drexel Institute for Biotechnology and Virology, 700 East Butler Avenue, Doylestown, Pennsylvania 18901Mary Ann Comunale - Drexel University College of Medicine and Department of Microbiology and Immunology and Drexel Institute for Biotechnology and Virology, 700 East Butler Avenue, Doylestown, Pennsylvania 18901Mengjun Wang - Drexel University College of Medicine and Department of Microbiology and Immunology and Drexel Institute for Biotechnology and Virology, 700 East Butler Avenue, Doylestown, Pennsylvania 18901Lucy Rodemich - Drexel University College of Medicine and Department of Microbiology and Immunology and Drexel Institute for Biotechnology and Virology, 700 East Butler Avenue, Doylestown, Pennsylvania 18901Jonathan Krakover - Drexel University College of Medicine and Department of Microbiology and Immunology and Drexel Institute for Biotechnology and Virology, 700 East Butler Avenue, Doylestown, Pennsylvania 18901Ramila Philip - Drexel University College of Medicine and Department of Microbiology and Immunology and Drexel Institute for Biotechnology and Virology, 700 East Butler Avenue, Doylestown, Pennsylvania 18901Jorge A Marrero - Drexel University College of Medicine and Department of Microbiology and Immunology and Drexel Institute for Biotechnology and Virology, 700 East Butler Avenue, Doylestown, Pennsylvania 18901Raymond A Dwek - Drexel University College of Medicine and Department of Microbiology and Immunology and Drexel Institute for Biotechnology and Virology, 700 East Butler Avenue, Doylestown, Pennsylvania 18901Timothy M Block - Drexel University College of Medicine and Department of Microbiology and Immunology and Drexel Institute for Biotechnology and Virology, 700 East Butler Avenue, Doylestown, Pennsylvania 18901
- Publication Details
- Journal of virology, v 82(3), pp 1259-1270
- Publisher
- American Society for Microbiology (ASM)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000252514000020
- Scopus ID
- 2-s2.0-38349150936
- Other Identifier
- 991014878285704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Virology