Journal article
Infertility and Its Treatments in Association with Autism Spectrum Disorders: A Review and Results from the CHARGE Study
International journal of environmental research and public health, v 10(8), pp 3715-3734
01 Aug 2013
PMID: 23965925
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Previous findings on relationships between infertility, infertility therapies, and autism spectrum disorders (ASD) have been inconsistent. The goals of this study are first, to briefly review this evidence and second, to examine infertility and its treatments in association with having a child with ASD in newly analyzed data. In review, we identified 14 studies published as of May 2013 investigating infertility and/or its treatments and ASD. Overall, prior results showed little support for a strong association, though some increases in risk with specific treatments were found; many limitations were noted. In new analyses of the CHildhood Autism Risk from Genetics and the Environment (CHARGE) population-based study, cases with autism spectrum disorder (ASD, n = 513) and controls confirmed to have typical development (n = 388) were compared with regard to frequencies of infertility diagnoses and treatments overall and by type. Infertility diagnoses and treatments were also grouped to explore potential underlying pathways. Logistic regression was used to obtain crude and adjusted odds ratios overall and, in secondary analyses, stratified by maternal age (= 35 years) and diagnostic subgroups. No differences in infertility, infertility treatments, or hypothesized underlying pathways were found between cases and controls in crude or adjusted analyses. Numbers were small for rarer therapies and in subgroup analyses; thus the potential for modest associations in specific subsets cannot be ruled out. However, converging evidence from this and other studies suggests that assisted reproductive technology is not a strong independent risk factor for ASD. Recommendations for future studies of this topic are provided.
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Details
- Title
- Infertility and Its Treatments in Association with Autism Spectrum Disorders: A Review and Results from the CHARGE Study
- Creators
- Kristen Lyall - University of California, DavisAlice Baker - Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USAIrva Hertz-Picciotto - Faculty of Public HealthCheryl K. Walker - Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USA
- Publication Details
- International journal of environmental research and public health, v 10(8), pp 3715-3734
- Publisher
- Mdpi
- Number of pages
- 20
- Grant note
- R01 ES015359; P01 ES11269 / NIEHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) P01ES011269 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) T32MH073124 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R829388; R833292; 5-T32MH073124 / EPA STAR; United States Environmental Protection Agency
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000330526700040
- Scopus ID
- 2-s2.0-84893403085
- Other Identifier
- 991020100207804721
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- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health