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Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Inhibitors of SARS-CoV‑2 Entry: Current and Future Opportunities
Journal of medicinal chemistry, v 63(21), pp 12256-12274
12 Nov 2020
PMID: 32539378
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recently, a novel coronavirus initially designated 2019-nCoV but now termed SARS-CoV-2 has emerged and raised global concerns due to its virulence. SARS-CoV-2 is the etiological agent of “coronavirus disease 2019”, abbreviated to COVID-19, which despite only being identified at the very end of 2019, has now been classified as a pandemic by the World Health Organization (WHO). At this time, no specific prophylactic or postexposure therapy for COVID-19 are currently available. Viral entry is the first step in the SARS-CoV-2 lifecycle and is mediated by the trimeric spike protein. Being the first stage in infection, entry of SARS-CoV-2 into host cells is an extremely attractive therapeutic intervention point. Within this review, we highlight therapeutic intervention strategies for anti-SARS-CoV, MERS-CoV, and other coronaviruses and speculate upon future directions for SARS-CoV-2 entry inhibitor designs.
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Details
- Title
- Inhibitors of SARS-CoV‑2 Entry: Current and Future Opportunities
- Creators
- Siyu Xiu - Shandong UniversityAlexej Dick - Drexel UniversityHan Ju - Shandong UniversitySako Mirzaie - Islamic Azad University Sanandaj BranchFatemeh Abdi - Islamic Azad University North Tehran BranchSimon Cocklin - Drexel UniversityPeng Zhan - Shandong UniversityXinyong Liu - Shandong University
- Publication Details
- Journal of medicinal chemistry, v 63(21), pp 12256-12274
- Publisher
- American Chemical Society; Washington, DC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000592734300009
- Scopus ID
- 2-s2.0-85090416965
- Other Identifier
- 991019169901804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Medicinal