Journal article
Interaction of cholesterol with saturated phospholipids: role of the C(17) side chain
Chemistry and physics of lipids, v 56(2), pp 217-222
1990
PMID: 2095992
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cholesterol and 5-androsten-3β-ol differ structurally only in the presence of an eight carbon side chain at the C(17) position in the former sterol. Both molecules decrease the main transition enthalpy change △
H in a series of phosphatidylcholines and phosphatidylethanolamines, of acyl chain length
n, with the reduction being a linear function of sterol concentration (
c). The sterol concentrations at which △
H = 0 bear a straight line relationship to
n and are equivalent for both cholesterol and 5-androsten-3β.ol In addition, both sterols give identical △
H versus
c slopes. These results underscore the importance of acyl chain length in the cholesterol/phospholipid interaction and also indicate that the cholesterol C(17) side group is not an essential requirement for the capacity of the sterol to decrease the enthalpy change of the main transition.
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Details
- Title
- Interaction of cholesterol with saturated phospholipids: role of the C(17) side chain
- Creators
- Michael A. Singer - Queen's UniversityLeonard Finegold - Drexel University
- Publication Details
- Chemistry and physics of lipids, v 56(2), pp 217-222
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1990ER77300015
- Scopus ID
- 2-s2.0-0025668819
- Other Identifier
- 991019173676704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics