Journal article
Intraspinal grafting of fibroblasts genetically modified by recombinant adenoviruses
Neuroreport, v 9(6), pp 1075-1079
20 Apr 1998
PMID: 9601670
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
INTRACEREBRAL or intraspinal grafting of genetically modified primary fibroblasts has been shown to enhance functional recovery in several models of CNS disease, including spinal cord injury. Most of these studies utilized retrovirus vectors. In this report, we describe in vitro conditions for genetically modifying primary fibroblasts with recombinant adenovirus vectors carrying the lacZ or green fluorescent protein (GFP) genes. As intraspinal allografts in animals immunosuppressed by cyclosporin A, the genetically modified cells survived and expressed the transgenes for at least 2 months. We conclude that recombinant adenovirus vectors are efficient and convenient tools for ex vivo gene therapy in the CNS.
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Details
- Title
- Intraspinal grafting of fibroblasts genetically modified by recombinant adenoviruses
- Creators
- Yi Liu - 1Department of Neurobiology and Anatomy, Allegheny University of the Health Sciences, 3200 Henry Avenue, Philadelphia, PA 19129 2Philadelphia Veterans Administration Hospital, Philadelphia, PA 19104, USAB HimesBrian TryonJon MoulStella ChowHao JinMarion MurrayAlan TesslerItzhak Fischer
- Publication Details
- Neuroreport, v 9(6), pp 1075-1079
- Publisher
- Lippincott-Raven Publishers
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000073497300023
- Scopus ID
- 2-s2.0-0032550124
- Other Identifier
- 991014877836404721
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- Web of Science research areas
- Neurosciences