Journal article
Laser flow measurements in an idealized total cavopulmonary connection with mechanical circulatory assistance
Artificial organs, v 35(11), pp 1052-1064
Nov 2011
PMID: 21955328
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study examined the interactive fluid dynamics between a cavopulmonary assist device and univentricular Fontan circulation. We conducted two-dimensional particle image velocimetry measurements on an idealized total cavopulmonary connection (TCPC) with an axial pump prototype intravascularly inserted into the inferior vena cava (IVC) and then in the IVC and the superior vena cava (SVC) for a dual-pump support case. The glass model of the TCPC consisted of rigid vessels having a diameter of 13.4 mm and a one-diameter vessel offset at the TCPC junction. Fluid velocity profiles were examined at a cardiac output of 3 L/min and SVC and IVC flow ratios of 30/70%, 40/60%, and 50/50% and pump rotational speeds from 3000 to 9000 rpm. In addition, cardiac outputs of 5 and 7 L/min were also examined. As compared to the flow profile with the pump present, the measured velocity field demonstrated the presence of rotational (i.e., out of plane) motion, which forced the higher-velocity regions toward the periphery of the vessel. As a result, few flow vortices were captured in the image plane downstream of the pump in the TCPC junction. However, the velocity profiles for all cases demonstrated the expected shunting preference of IVC flow toward the right pulmonary artery. Furthermore, the inclusion of the pump provided a pressure rise of 3 to 9 mm Hg, which would be sufficient to relieve systemic hypertension in Fontan patients with circulatory dysfunction.
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Details
- Title
- Laser flow measurements in an idealized total cavopulmonary connection with mechanical circulatory assistance
- Creators
- Steven G Chopski - Department of Mechanical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA, USAEmily DownsChristopher M HaggertyAjit P YoganathanAmy L Throckmorton
- Publication Details
- Artificial organs, v 35(11), pp 1052-1064
- Publisher
- Wiley; United States
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000297201200012
- Scopus ID
- 2-s2.0-81855192794
- Other Identifier
- 991014878106804721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Transplantation