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Lung function, percent emphysema, and QT duration: The Multi-Ethnic Study of Atherosclerosis (MESA) lung study
Journal article   Open access   Peer reviewed

Lung function, percent emphysema, and QT duration: The Multi-Ethnic Study of Atherosclerosis (MESA) lung study

Hilary F. Armstrong, Gina S. Lovasi, Elsayed Z. Soliman, Susan R. Heckbert, Bruce M. Psaty, John H. M. Austin, Jerry A. Krishnan, Eric A. Hoffman, Craig Johnson, Matthew J. Budoff, …
Respiratory medicine, v 123, pp 1-7
01 Feb 2017
DOI: https://doi.org/10.1016/j.rmed.2016.12.003
PMID: 28137484
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
http://www.resmedjournal.com/article/S0954611116303249/pdfView
Published, Version of Record (VoR) Open
url
https://doi.org/10.1016/j.rmed.2016.12.003View
Published, Version of Record (VoR) Open

Abstract

Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Life Sciences & Biomedicine Respiratory System Science & Technology
Background: The QT interval on electrocardiogram (ECG) reflects ventricular repolarization; a prolonged QT interval is associated with increased mortality risk. Prior studies suggest an association between chronic obstructive pulmonary disease (COPD) and prolonged QT interval. However, these studies were small and often enrolled hospital-based samples. We tested the hypotheses that lower lung function and increased percent emphysema on computed tomography (CT) are associated with, a prolonged QT interval in a general population sample and additionally in those with COPD. Methods: As part of the Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study, we assessed spirometry, full-lung CT scans, and ECGs in participants aged 45-84 years. The QT on ECGs was corrected for heart rate (QTc) using the Framingham formula. QTc values = 460 msec in women and >= 450 msec in men were considered abnormal (prolonged QTc). Multivariate regression models were used to examine the cross-sectional association between pulmonary measures and QTc. Results: The mean age of the sample of 2585 participants was 69 years, and 47% were men. There was an inverse association between FEV1%, FVC%, FEV1/FVC%, emphysema, QTc duration and prolonged QTc. Gender was a significant interaction term, even among never smokers. Having severe COPD was also associated with QTc prolongation. Conclusions: Our analysis revealed a significant association between lower lung function and longer QTc in men but not in women in a population-based sample. Our findings suggest the possibility of gender differences in the risk of QTc-associated arrhythmias in a population-based sample. (C) 2016 Elsevier Ltd. All rights reserved.

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12 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Cardiac & Cardiovascular Systems
Respiratory System
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