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Journal article
MXene-based platforms for angiogenesis and vascular regeneration
Chemical engineering journal, v 540, Forthcoming
19 Apr 2026
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
Angiogenesis, the process of new blood vessel formation, is pivotal for tissue repair, wound healing, and the treatment of ischemic diseases. MXenes, a rapidly expanding family of two-dimensional transition-metal carbides, nitrides, and carbonitrides, combine high specific surface area, tunable surface chemistry, intrinsic electrical conductivity, and strong photothermal responsiveness, positioning them as promising materials for vascular regeneration. This review summarizes the cellular and molecular mechanisms through which MXenes promote angiogenesis, including improved endothelial cell uptake, modulation of reactive oxygen species, and controlled delivery of pro-angiogenic cues. We survey emerging MXene-enabled platforms, such as conductive hydrogels, three-dimensional printed scaffolds, photothermal wound dressings, and implant coatings that demonstrate accelerated neovascularization in preclinical models of wound-healing, bone-repair, and ischemia. Key translational challenges, including long-term biocompatibility, biodegradability, scalable and sustainable synthesis, and regulatory considerations, are critically discussed. Finally, we outline strategic directions for the field, including integration of MXenes into biodegradable polymer matrices, development of stimuli-responsive delivery systems for precision angiogenic therapy, and establishment of standardized manufacturing and regulatory pathways. Addressing these challenges through interdisciplinary efforts will be essential for translating MXene-based angiogenic technologies into clinically viable regenerative therapies.
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Details
- Title
- MXene-based platforms for angiogenesis and vascular regeneration
- Creators
- Elham Vojoudi - Drexel UniversityHossein Vojoudi - Drexel University, Chemical and Biological EngineeringMasoud Soroush (Corresponding Author) - Drexel University, Chemical and Biological Engineering
- Publication Details
- Chemical engineering journal, v 540, Forthcoming
- Publisher
- Elsevier
- Number of pages
- 44
- Grant note
- U.S. National Science Foundation: CMMI-2134607
M.S. and H.V. would like to acknowledge financial support from the U.S. National Science Foundation under Grant No. CMMI-2134607. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:001779339800001
- Scopus ID
- 2-s2.0-105039170962
- Other Identifier
- 991022172969104721
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InCites Highlights
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- Web of Science research areas
- Engineering, Chemical
- Engineering, Environmental