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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Maternal Dietary Factors and the Risk of Autism Spectrum Disorders: A Systematic Review of Existing Evidence
Autism research, v 13(10), pp 1634-1658
01 Oct 2020
PMID: 33015977
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Prenatal maternal diet is a critical factor in offspring neurodevelopment. Emerging evidence suggests that prenatal diet may also play a role in the etiology autism spectrum disorder (ASD). This review summarizes studies published in English that examined prenatal nutrients or maternal diet in association with ASD from PubMed as of July 2020. Thiry-six studies from nine countries were included in this systematic review; these focused on multivitamin (n= 5), prenatal vitamin (n= 3), folic acid (FA;n= 14), Vitamin D (n= 11), polyunsaturated fatty acid or fish/supplement intake (n= 7), iron (n= 3), Vitamin B12 (n= 1), calcium (n= 1), magnesium (n= 1), and broad maternal dietary habits (n= 3). Overall, higher or moderate intake of prenatal/multivitamin, FA, and Vitamin D was associated with reductions in odds of ASD, though results have not been uniform and there is a need to clarify differences in findings based on biomarkers versus reported intake. Evidence was inconclusive or insufficient for other nutrients. Differences in the timing and measurement of these dietary factors, as well as potential residual confounding, may contribute to existing discrepancies. Key areas for future research to better understand the role of maternal diet in ASD include the need to address potential critical windows, examine the combined effect of multiple nutrients, and consider interactions with genetic or environmental factors. Lay Summary Maternal diet during pregnancy is important for child neurodevelopment. We reviewed 36 studies examining maternal diet and autism spectrum disorder (ASD) and found that prenatal vitamin/multivitamin use and adequate intake of folic acid and Vitamin D were each associated with lower likelihood of having a child with ASD. Future studies on these and other dietary factors are needed to better understand the role of maternal diet in the development of ASD.
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Details
- Title
- Maternal Dietary Factors and the Risk of Autism Spectrum Disorders: A Systematic Review of Existing Evidence
- Creators
- Caichen Zhong - Drexel UniversityJillian Tessing - Yale New Haven HospitalBrian K. Lee - Drexel UniversityKristen Lyall - Center for Autism and Related Disorders
- Publication Details
- Autism research, v 13(10), pp 1634-1658
- Publisher
- Wiley
- Number of pages
- 25
- Grant note
- 1R01NS107607-01A1 / NINDS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) 1R21HD096356-01 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA W81XWH-16-1-0753 / Department of Defense grant; United States Department of Defense Eagles Autism Challenge
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics; A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000574900500001
- Scopus ID
- 2-s2.0-85092030855
- Other Identifier
- 991019168733204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Behavioral Sciences
- Psychology, Developmental