Journal article
Maternal Dietary Fat Intake in Association With Autism Spectrum Disorders
American journal of epidemiology, v 178(2), pp 209-220
15 Jul 2013
PMID: 23813699
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Our goal in this study was to determine whether maternal fat intake before or during pregnancy was associated with risk of autism spectrum disorder (ASD) in the offspring. Our primary analysis included 317 mothers who reported a child with ASD and 17,728 comparison mothers from the Nurses' Health Study II (index births in 1991-2007). Dietary information was collected prospectively through a validated food frequency questionnaire. Binomial regression was used to estimate crude and adjusted risk ratios. Maternal intake of linoleic acid was significantly inversely associated with ASD risk in offspring, corresponding to a 34% reduction in risk in the highest versus lowest quartiles of intake. Mothers in the lowest 5% of omega-3 fatty acid intake had a significant increase in offspring ASD risk as compared with the remaining distribution (risk ratio = 1.53, 95% confidence interval: 1.00, 2.32); this association was also seen in the subgroup of women (86 cases and 5,798 noncases) for whom dietary information during pregnancy was available (risk ratio = 2.42, 95% confidence interval: 1.19, 4.91). Thus, variations in intake of polyunsaturated fats within the range commonly observed among US women could affect fetal brain development and ASD risk. Because the number of women with diet assessed during pregnancy was small, however, these results should be interpreted cautiously.
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Details
- Title
- Maternal Dietary Fat Intake in Association With Autism Spectrum Disorders
- Creators
- Kristen Lyall - Harvard UniversityKassandra L. Munger - Harvard UniversityEilis J. O'Reilly - Harvard UniversitySusan L. Santangelo - Harvard UniversityAlberto Ascherio - Harvard University
- Publication Details
- American journal of epidemiology, v 178(2), pp 209-220
- Publisher
- Oxford Univ Press
- Number of pages
- 12
- Grant note
- T32 MH073124 / NIMH NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) T32MH073124 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000322021300006
- Scopus ID
- 2-s2.0-84880547899
- Other Identifier
- 991020099050304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health