Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Maternal Early Life Factors Associated with Hormone Levels and the Risk of Having a Child with an Autism Spectrum Disorder in the Nurses Health Study II
Journal of autism and developmental disorders, Vol.41(5), pp.618-627
01 May 2011
PMCID: PMC3494408
PMID: 20700638
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
It is not known whether reproductive factors early in the mother’s life influence risk of autism spectrum disorders (ASD). We assessed maternal age at menarche, menstrual cycle characteristics during adolescence, oral contraceptive use prior to first birth, body shape, and body mass index (BMI) in association with ASD using binomial regression in a cohort study of 61,596 women, including 743 cases. Overall, early life factors were not associated with ASD, though early age at menarche (RR for age 10 or less = 1.54, 95% CI 1.18, 2.02,
p
= 0.0002) and BMI at age 18 of ≥30 (RR 2.03, 95% CI 1.34, 3.08,
p
= 0.0008) were significantly associated with increased risk of ASD. Further work should investigate the potential influence of these factors.
Metrics
5 Record Views
Details
- Title
- Maternal Early Life Factors Associated with Hormone Levels and the Risk of Having a Child with an Autism Spectrum Disorder in the Nurses Health Study II
- Creators
- Kristen Lyall - Harvard UniversityDavid L. Pauls - Massachusetts General HospitalSusan Santangelo - Massachusetts General HospitalDonna Spiegelman - Departments of Epidemiology and BiostatisticsAlberto Ascherio - Brigham and Women's Hospital
- Publication Details
- Journal of autism and developmental disorders, Vol.41(5), pp.618-627
- Publisher
- Springer Nature
- Grant note
- R01 CA050385 || CA / National Cancer Institute : NCI
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Identifiers
- 991020100053504721
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Web of Science research areas
- Psychology, Developmental