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Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay
Journal article   Open access   Peer reviewed

Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay

Kristen Lyall, Paul Ashwood, Judy Van de Water and I. Hertz-Picciotto
Journal of autism and developmental disorders, v 44(7), pp 1546-1555
01 Jul 2014
DOI: https://doi.org/10.1007/s10803-013-2017-2
PMID: 24337796
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc4104679View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Allergy Asthma Autism Autoimmune disease Developmental delay Maternal risk factors
The maternal immune system may play a role in offspring neurodevelopment. We examined whether maternal autoimmune disease, asthma, and allergy were associated with child autism spectrum disorder (ASD) and developmental delay without autism (DD) using 560 ASD cases, 391 typically developing controls, and 168 DD cases from the CHildhood Autism Risk from Genetics and the Environment (CHARGE) study. Results from conditional logistic regression demonstrated few significant associations overall. Maternal autoimmune disease was significantly associated with a modest increase in odds of developmental disorders (combined ASD + DD; OR = 1.46, 95 % CI 1.01, 2.09) but not of ASD alone. Associations with certain allergens and onset periods were also suggested. These findings suggest maternal autoimmune disease may modestly influence childhood developmental disorders (ASD + DD).

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79 citations in Web of Science
76 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Web of Science research areas
Psychology, Developmental
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