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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay
Journal of autism and developmental disorders, v 44(7), pp 1546-1555
01 Jul 2014
PMCID: PMC4104679
PMID: 24337796
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The maternal immune system may play a role in offspring neurodevelopment. We examined whether maternal autoimmune disease, asthma, and allergy were associated with child autism spectrum disorder (ASD) and developmental delay without autism (DD) using 560 ASD cases, 391 typically developing controls, and 168 DD cases from the CHildhood Autism Risk from Genetics and the Environment (CHARGE) study. Results from conditional logistic regression demonstrated few significant associations overall. Maternal autoimmune disease was significantly associated with a modest increase in odds of developmental disorders (combined ASD + DD; OR = 1.46, 95 % CI 1.01, 2.09) but not of ASD alone. Associations with certain allergens and onset periods were also suggested. These findings suggest maternal autoimmune disease may modestly influence childhood developmental disorders (ASD + DD).
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Details
- Title
- Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay
- Creators
- Kristen Lyall - College Station Medical CenterPaul Ashwood - University of California, DavisJudy Van de Water - University of California, DavisI. Hertz-Picciotto - Department of Public Health Sciences, Univeristy of California, Davis, USA
- Publication Details
- Journal of autism and developmental disorders, v 44(7), pp 1546-1555
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000337752800005
- Scopus ID
- 2-s2.0-84903589945
- Other Identifier
- 991020099920004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Psychology, Developmental