Journal article
Mechanical and interventional support for heart failure with preserved ejection fraction: A review
Artificial organs
17 May 2022
PMID: 35579447
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Restrictive cardiomyopathy (RCM) and hypertrophic cardiomyopathy (HCM) are two disease processes that are known to progress to heart failure with preserved ejection fraction (HFpEF). Pharmacologic therapies for HFpEF have not improved patient outcomes or reduced mortality in this patient cohort; thus, there continues to be substantial interest in other treatment strategies, including surgical interventions and devices. In this article, we explore and report the current utility of percutaneous therapies and surgically implanted mechanical support in the treatment of patients with HFpEF.
Treatment strategies include percutaneous interventions with interatrial shunts, left atrial assist devices (LAADs), and ventricular assist devices (VADs) in various configurations. Although VADs have been employed to treat patients with heart failure with reduced ejection fraction, their efficacy is limited in those with RCM and HCM. A left atrial-to-aortic VAD has been proposed to directly unload the left atrium, but data is limited. Alternatively, a LAAD could be placed in the mitral position and simultaneously unload the left atrium, while filling the left ventricle.
A left atrial assist device in the mitral position is a promising solution to address the hemodynamic abnormalities in RCM and HCM; these pumps, however, are still under development.
Metrics
Details
- Title
- Mechanical and interventional support for heart failure with preserved ejection fraction: A review
- Creators
- Jonathan S Gordon - Thomas Jefferson UniversityCameron M Blazoski - Thomas Jefferson UniversityChelsey T Wood - Thomas Jefferson UniversityCharlotte Zuber - Thomas Jefferson UniversityHoward T Massey - Thomas Jefferson UniversityAmy Throckmorton - Drexel UniversityVakhtang Tchantchaleishvili - Thomas Jefferson University
- Publication Details
- Artificial organs
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000796566900001
- Scopus ID
- 2-s2.0-85132105734
- Other Identifier
- 991019168504704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Transplantation