Journal article
Myocardial Stunning: Association with Altered Gene Expression
Journal of cardiac surgery, v 9(3S), pp 537-542
May 1994
PMID: 8069049
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Regional and global myocardial ischemia and reperfusion have been demonstrated to induce expression of the stress response protein heat shock 70 (HSP70) and of immediate early genes, c‐jun, c‐fos, and c‐myc. Because of the models that have been utilized, it has not been possible to discriminate whether this response is the consequence of ischemia, reperfusion, or abnormal hemodynamic stress superimposed on stunned myocardium. In a nonworking isolated and blood‐perfused rat heart model, we evaluated the mRNAs for c‐fos, c‐myc, and hsp70. The heart was subjected to varying periods of ischemia and reperfusion. Significant increases in hsp70 and c‐fos were observed, which increased with longer periods of ischemia. No significant increase In c‐myc was measured. In addition, mRNA encoding the Ca2+/glucose responsive stress protein GRP78 was evaluated. No increase In this early response gene was noted despite the use of a model associated with cellular calcium loading. Based on these observations, we suggest that the induction of hsp70 and c‐fos is the consequence of ischemia and reperfusion and not dependent upon an early hypertrophy response such as would be observed in afterload mismatching or on calcium loading. Further investigations are necessary to isolate the effects of ischemia from those of reperfusion.
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Details
- Title
- Myocardial Stunning: Association with Altered Gene Expression
- Creators
- Andrew S. Wechsler - Virginia Commonwealth University Medical CenterJohn W.C. EntwistleMai Ding - Virginia Commonwealth University Medical CenterThomas Yeh - Virginia Commonwealth University Medical CenterEmma R. Jakoi - Virginia Commonwealth University Medical Center
- Publication Details
- Journal of cardiac surgery, v 9(3S), pp 537-542
- Publisher
- Wiley
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; [Retired Faculty]
- Web of Science ID
- WOS:A1994NP09700029
- Scopus ID
- 2-s2.0-0028285296
- Other Identifier
- 991020705489404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Surgery