Journal article
Neighborhood characteristics and incident myocardial infarction in US older adults: evaluation in two nationwide cohorts
American journal of epidemiology, v 194(9), pp 2733-2743
29 Apr 2025
PMID: 40302120
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Inconsistent findings on the associations of adverse neighborhood context with myocardial infarction (MI) or racial disparities in MI may reflect publication bias or chance. We compared results from harmonized analyses of the REasons for Geographic and Racial Differences in Stroke (REGARDS, n=25,143, aged ≥ 45 years, 42% Black; 2003-2018) study and the Health and Retirement Study (HRS, n=14,1941, aged > 50 years, 13% Black; 2004-2018). For both cohorts, we used 51 American Community Survey (ACS) census tract variables to predict hazard of incident MI using Cox models. We evaluated consistency of coefficients and Black-White differences in coefficients between cohorts. Cumulative MI incidence in REGARDS (6.2% over 11.5 years median follow-up) was similar to HRS (7.1% over 13.1 years median follow-up). Of 51 ACS predictors evaluated, the log(HR) for incident MI differed by <=0.05 between REGARDS and HRS for 34 variables. Of the 12 census tract predictors with significantly different associations with MI for Black versus White respondents in REGARDS, none showed interactions with race in HRS at the p<0.05 threshold. Neighborhood socioeconomic associations with MI across two national studies were largely replicable. Racial differences in associations were inconsistent.
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Details
- Title
- Neighborhood characteristics and incident myocardial infarction in US older adults: evaluation in two nationwide cohorts
- Creators
- Kendra D Sims (Corresponding Author) - University of California, San FranciscoTorsten B Neilands - University of California, San FranciscoJulene K Johnson - University of California, San FranciscoLoni P Tabb - Drexel UniversityMonika M Safford - Cornell UniversityGina S Lovasi - Drexel UniversitySuzanne E Judd - University of Alabama at BirminghamKirsten Bibbins-Domingo - American Medical AssociationM Maria Glymour - Boston University
- Publication Details
- American journal of epidemiology, v 194(9), pp 2733-2743
- Publisher
- Oxford University Press
- Number of pages
- 11
- Grant note
- This work was funded by National Institutes of Health grants (K99AG083121 to K.D.S., 2P30AG015272-21 to K.D.S., T.B.N., and J.K.J., T32AG049663 to K.D.S., R56AG049970 to G.S.L., R01HL165452 to M.M.S., and R01AG072681 to M.M.G.).
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Dana and David Dornsife School of Public Health; Epidemiology and Biostatistics
- Web of Science ID
- WOS:001541156100001
- Scopus ID
- 2-s2.0-105015430017
- Other Identifier
- 991022051452004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health