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Journal article
Neighborhood physical activity facilities predict risk of incident mixed and vascular dementia: The Cardiovascular Health Cognition Study
Alzheimer's & dementia, v 21(1), e14387
01 Jan 2025
PMID: 39559999
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
INTRODUCTION
Neighborhood environments may promote neurocognitive health in part by providing amenities that encourage physical activity. We examined associations between quantity of walkable facilities, including specifically physical activity facilities (e.g., gyms, recreation centers), with risk of incident dementia.
METHODS
Participants included 2923 adults ≥ 65 years old from the Cardiovascular Health Cognition Study (1992–1999), with clinically adjudicated dementia classified over a median 6.0 years of follow‐up. Walkable facilities were measured within 1 km (Euclidean) of home. Self‐reported baseline physical activity was considered a moderator.
RESULTS
In adjusted Cox models, participants with ≥ 2 (vs. 0) physical activity facilities had reduced risk of mixed/vascular dementia, but not Alzheimer's disease, particularly after excluding individuals in the bottom 20th percentile of physical activity (hazard ratio = 0.56, 95% confidence interval: 0.35–0.89).
DISCUSSION
Neighborhood amenities that encourage physical activity may mitigate dementia risk via improved vascular health, especially for individuals with sufficient baseline mobility to use these resources. Highlights We examined associations between nearby walkable facilities and incident dementia. Facilities within 1 km were counted via the National Establishment Time Series Database. More physical activity facilities predicted lower risk of mixed/vascular dementia. No associations were found between walkable facilities and incident Alzheimer's disease.
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Details
- Title
- Neighborhood physical activity facilities predict risk of incident mixed and vascular dementia: The Cardiovascular Health Cognition Study
- Creators
- Kyle D. Moored - Johns Hopkins UniversityMichael R. Desjardins - Johns Hopkins UniversityBreanna M. Crane - Johns Hopkins UniversityPatrick T. Donahue - Johns Hopkins UniversityEmily A. Richards - Johns Hopkins UniversityJana A. Hirsch - Drexel UniversityGina S. Lovasi - Drexel UniversityAndrea L. Rosso - University of PittsburghParveen K. Garg - University of Southern CaliforniaTimothy M. Shields - Johns Hopkins UniversityFrank C. Curriero - Johns Hopkins UniversityMichelle C. Odden - Stanford Health CareOscar L. Lopez - University of PittsburghMary L. Biggs - University of WashingtonAnne B. Newman - University of PittsburghMichelle C. Carlson - Johns Hopkins University
- Publication Details
- Alzheimer's & dementia, v 21(1), e14387
- Publisher
- WILEY
- Number of pages
- 11
- Grant note
- Pennsylvania Department of Health: HHSN268201200036C, HHSN268200800007C, HHSN268201800001C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, 75N92021D00006, R01HL14843, U01HL080295, U01HL130114 National Heart, Lung, and Blood Institute (NHLBI): R01AG049970, R01AG049970-S1, R56AG049970, R01AG023629, R01AG072634 National Institute of Neurological Disorders and Stroke (NINDS)National Institute on Aging (NIA): R01AA028552 National Institute on Alcohol Abuse and Alcoholism: 4100072543 Commonwealth Universal Research Enhancement (C.U.R.E) program - Pennsylvania Department of HealthUrban Health Collaborative at Drexel University, the Built Environment and Health Research Group at Columbia University: T32-AG000247 Johns Hopkins Epidemiology and Biostatistics of Aging Research FellowshipUniversity of Pittsburgh Older Adults Independence Center: P30 AG024827 The authors thank the CHS participants for giving their time and effort to the study for more than 30 years. This research was supported by the Neighborhoods, Cognitive Aging, and Modifiable Risk Factors ancillary to the Cardiovascular Health Study (PI: Michelle C. Carlson, NIA R01AG055404). This research was also supported by contracts HHSN268201200036C, HHSN268200800007C, HHSN268201800001C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, 75N92021D00006, and grants R01HL14843, U01HL080295, and U01HL130114 from the National Heart, Lung, and Blood Institute (NHLBI), with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS). Additional support was provided by grants R01AG049970, R01AG049970-S1, R56AG049970, R01AG023629, and R01AG072634 from the National Institute on Aging (NIA) and R01AA028552 from the National Institute on Alcohol Abuse and Alcoholism. This work was further supported by Commonwealth Universal Research Enhancement (C.U.R.E) program funded by the Pennsylvania Department of Health - 2015 Formula award-SAP #4100072543, the Urban Health Collaborative at Drexel University, the Built Environment and Health Research Group at Columbia University, and the Brain Health Study Research Group at Johns Hopkins Bloomberg School of Public Health. Dr. Breanna Crane and Dr. Patrick Donahue were supported by the Johns Hopkins Epidemiology and Biostatistics of Aging Research Fellowship (T32-AG000247). Dr. Newman was supported in part by the University of Pittsburgh Older Adults Independence Center P30 AG024827. A full list of principal CHS investigators and institutions can be found at CHS-NHLBI.org. Funding sources had no role in study design, writing, or decision to submit this manuscript for publication.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Dana and David Dornsife School of Public Health; Epidemiology and Biostatistics
- Web of Science ID
- WOS:001359009300001
- Scopus ID
- 2-s2.0-85209778636
- Other Identifier
- 991021962015104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology