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Journal article
Neuronal abnormalities in microtubule-associated protein 1B mutant mice
Proceedings of the National Academy of Sciences - PNAS, v 93(3), pp 1270-1275
06 Feb 1996
PMID: 8577753
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Abstract
Microtubules play an important role in establishing cellular architecture. Neuronal microtubules are considered to have a role in dendrite and axon formation. Different portions of the developing and adult brain microtubules are associated with different microtubule-associated proteins (MAPs). The roles of each of the different MAPs are not well understood. One of these proteins, MAP1B, is expressed in different portions of the brain and has been postulated to have a role in neuronal plasticity and brain development. To ascertain the role of MAP1B, we generated mice which carry an insertion in the gene by gene-targeting methods. Mice which are homozygous for the modification die during embryogenesis. The heterozygotes exhibit a spectrum of phenotypes including slower growth rates, lack of visual acuity in one or both eyes, and motor system abnormalities. Histochemical analysis of the severely affected mice revealed that their Purkinje cell dendritic processes are abnormal, do not react with MAP1B antibodies, and show reduced staining with MAP1A antibodies. Similar histological and immunochemical changes were observed in the olfactory bulb, hippocampus, and retina, providing a basis for the observed phenotypes.
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Details
- Title
- Neuronal abnormalities in microtubule-associated protein 1B mutant mice
- Creators
- W Edelmann - Albert Einstein College of MedicineM Zervas - Yeshiva UniversityP Costello - Yeshiva UniversityL Roback - Yeshiva UniversityI Fischer - Drexel UniversityJ A Hammarback - Wake Forest UniversityN Cowan - New York UniversityP Davies - Yeshiva UniversityB Wainer - Yeshiva UniversityR Kucherlapati - Yeshiva University
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 93(3), pp 1270-1275
- Publisher
- PNAS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1996TU64000058
- Scopus ID
- 2-s2.0-9044222485
- Other Identifier
- 991019168881204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences