Files and links (1)
Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
New RAD51 Inhibitors to Target Homologous Recombination in Human Cells
Genes, v 12(6), p920
01 Jun 2021
PMID: 34208492
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Targeting DNA repair proteins with small-molecule inhibitors became a proven anti-cancer strategy. Previously, we identified an inhibitor of a major protein of homologous recombination (HR) RAD51, named B02. B02 inhibited HR in human cells and sensitized them to chemotherapeutic drugs in vitro and in vivo. Here, using a medicinal chemistry approach, we aimed to improve the potency of B02. We identified the B02 analog, B02-isomer, which inhibits HR in human cells with significantly higher efficiency. We also show that B02-iso sensitizes triple-negative breast cancer MDA-MB-231 cells to the PARP inhibitor (PARPi) olaparib.
Metrics
Details
- Title
- New RAD51 Inhibitors to Target Homologous Recombination in Human Cells
- Creators
- Irina S. Shkundina - Drexel UniversityAlexander A. Gall - IDbyDNA, Bothell, WA 89011, USA.Alexej Dick - Drexel UniversitySimon Cocklin - Drexel UniversityAlexander Mazin - Drexel University
- Publication Details
- Genes, v 12(6), p920
- Publisher
- Mdpi
- Number of pages
- 21
- Grant note
- R01 CA188347; P30CA056036 / NCI: National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01AI150491 / NIH/NIAID; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000666312800001
- Scopus ID
- 2-s2.0-85108870253
- Other Identifier
- 991019168544604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Genetics & Heredity