Journal article
Novel fucosylated biomarkers for the early detection of hepatocellular carcinoma
Cancer epidemiology, biomarkers & prevention, v 18(6), pp 1914-1921
Jun 2009
PMID: 19454616
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Changes in glycosylation, most notably fucosylation, have been associated with the development of hepatocellular carcinoma (HCC). In this report, the levels of fucosylated kininogen (Fc-Kin) and fucosylated alpha-1-antitrypsin were analyzed individually and in combination with the currently used marker, alpha-fetoprotein, and a previously identified biomarker, Golgi protein 73 (GP73), for the ability to distinguish between a diagnosis of cirrhosis and HCC. This analysis was done on serum from 113 patients with cirrhosis and 164 serum samples from patients with cirrhosis plus HCC. The levels of Fc-Kin and fucosylated alpha-1-antitrypsin were significantly higher in patients with HCC compared with those with cirrhosis (P < 0.0001). Greatest performance was achieved through the combination of Fc-Kin, alpha-fetoprotein, and GP73, giving an optimal sensitivity of 95%, a specificity of 70%, and an area under the receiver operating characteristic of 0.94. In conclusion, the altered glycosylation of serum glycoproteins can act as potential biomarkers of primary HCC when used independently or in combination with other markers of HCC.
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Details
- Title
- Novel fucosylated biomarkers for the early detection of hepatocellular carcinoma
- Creators
- Mengjun Wang - Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virology, Drexel University College of Medicine, Doylestown, Pennsylvania, USARonald E LongMary Ann ComunaleOmer JunaidiJorge MarreroAdrian M Di BisceglieTimothy M BlockAnand S Mehta
- Publication Details
- Cancer epidemiology, biomarkers & prevention, v 18(6), pp 1914-1921
- Publisher
- American Association for Cancer Research (AACR); United States
- Grant note
- R41 CA121506-01A1 / NCI NIH HHS UO1 CA084951-06 / NCI NIH HHS R01 CA120206 / NCI NIH HHS R41 CA121506 / NCI NIH HHS U01 CA084951 / NCI NIH HHS R01 CA120206-01 / NCI NIH HHS R42 CA121506-02 / NCI NIH HHS R01 CA120206-01A1 / NCI NIH HHS R42 CA121506 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000266754100036
- Scopus ID
- 2-s2.0-67449107963
- Other Identifier
- 991014878212304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Public, Environmental & Occupational Health