Journal article
Numerical, Hydraulic, and Hemolytic Evaluation of an Intravascular Axial Flow Blood Pump to Mechanically Support Fontan Patients
Annals of biomedical engineering, v 39(1), pp 324-336
Jan 2011
PMID: 20839054
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Currently available mechanical circulatory support systems are limited for adolescent and adult patients with a Fontan physiology. To address this growing need, we are developing a collapsible, percutaneously-inserted, axial flow blood pump to support the cavopulmonary circulation in Fontan patients. During the first phase of development, the design and experimental evaluation of an axial flow blood pump was performed. We completed numerical modeling of the pump using computational fluid dynamics analysis, hydraulic testing of a plastic pump prototype, and blood bag experiments (n = 7) to measure the levels of hemolysis produced by the pump. Statistical analyses using regression were performed. The prototype with a 4-bladed impeller generated a pressure rise of 2–30 mmHg with a flow rate of 0.5–4 L/min for 3000–6000 RPM. A comparison of the experimental performance data to the numerical predictions demonstrated an excellent agreement with a maximum deviation being less than 6%. A linear increase in the plasma-free hemoglobin (pfHb) levels during the 6-h experiments was found, as desired. The maximum pfHb level was measured to be 21 mg/dL, and the average normalized index of hemolysis was determined to be 0.0097 g/100 L for all experiments. The hydraulic performance of the prototype and level of hemolysis are indicative of significant progress in the design of this blood pump. These results support the continued development of this intravascular pump as a bridge‐to‐transplant, bridge‐to‐recovery, bridge-to-hemodynamic stability, or bridge-to-surgical reconstruction for Fontan patients.
Metrics
Details
- Title
- Numerical, Hydraulic, and Hemolytic Evaluation of an Intravascular Axial Flow Blood Pump to Mechanically Support Fontan Patients
- Creators
- Amy Throckmorton - Department of Mechanical Engineering, School of Engineering Virginia Commonwealth University 401 West Main Street, Rm. E3221 P.O. Box 843015 Richmond VA 23284 USAJugal Kapadia - Department of Mechanical Engineering, School of Engineering Virginia Commonwealth University 401 West Main Street, Rm. E3221 P.O. Box 843015 Richmond VA 23284 USASteven Chopski - Department of Mechanical Engineering, School of Engineering Virginia Commonwealth University 401 West Main Street, Rm. E3221 P.O. Box 843015 Richmond VA 23284 USASonya Bhavsar - Department of Mechanical Engineering, School of Engineering Virginia Commonwealth University 401 West Main Street, Rm. E3221 P.O. Box 843015 Richmond VA 23284 USAWilliam Moskowitz - The Division of Pediatric Cardiology, Medical College of Virginia Virginia Commonwealth University Richmond VA USAScott Gullquist - The Division of Pediatric Cardiology, Medical College of Virginia Virginia Commonwealth University Richmond VA USAJames Gangemi - The Division of Thoracic and Cardiovascular Surgery, School of Medicine University of Virginia Charlottesville VA USAChristopher Haggerty - The Wallace H. Coulter School of Biomedical Engineering Georgia Institute of Technology and Emory University Atlanta GA USAAjit Yoganathan - The Wallace H. Coulter School of Biomedical Engineering Georgia Institute of Technology and Emory University Atlanta GA USA
- Publication Details
- Annals of biomedical engineering, v 39(1), pp 324-336
- Publisher
- Springer; Boston
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000287213100028
- Scopus ID
- 2-s2.0-78650884316
- Other Identifier
- 991014877679704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical