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Parental social responsiveness and risk of autism spectrum disorder in offspring
Journal article   Open access   Peer reviewed

Parental social responsiveness and risk of autism spectrum disorder in offspring

Kristen Lyall, John N Constantino, Marc G Weisskopf, Andrea L Roberts, Alberto Ascherio and Susan L Santangelo
JAMA psychiatry (Chicago, Ill.), v 71(8), pp 936-942
Aug 2014
DOI: https://doi.org/10.1001/jamapsychiatry.2014.476
PMID: 25100167
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc4126195View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Adolescent Adult Case-Control Studies Child Child Development Disorders, Pervasive - epidemiology Child Development Disorders, Pervasive - genetics Child, Preschool Fathers - psychology Female Genetic Predisposition to Disease Humans Longitudinal Studies Male Middle Aged Mothers - psychology Psychiatric Status Rating Scales Random Allocation Risk Sex Factors Social Behavior United States - epidemiology Young Adult
Although autism spectrum disorder (ASD) is known to be heritable, patterns of inheritance of subclinical autistic traits in nonclinical samples are poorly understood. To examine the familiality of Social Responsiveness Scale (SRS) scores of individuals with and without ASD. We performed a nested case-control study (pilot study: July 1, 2007, through June 30, 2009; full-scale study: September 15, 2008, through September 14, 2012) within a population-based longitudinal cohort. Participants were drawn from the Nurses' Health Study II, a cohort of 116,430 female nurses recruited in 1989. Case participants were index children with reported ASD; control participants were frequency matched by year of birth of case participants among those not reporting ASD. Of 3161 eligible participants, 2144 nurses (67.8%) returned SRS forms for a child and at least 1 parent and were included in these analyses. The SRS scores, as reported by nurse mothers and their spouses, were examined in association with risk of ASD using crude and adjusted logistic regression analyses. The SRS scores of the children were examined in association with SRS scores of the parents using crude and adjusted linear regression analyses stratified by case status. Autism spectrum disorder, assessed by maternal report, validated in a subgroup with the Autism Diagnostic Interview-Revised. A total of 1649 individuals were included in these analyses, including 256 ASD case participants, 1393 control participants, 1233 mothers, and 1614 fathers. Risk of ASD was increased by 85.0% among children whose parents had concordantly elevated SRS scores (odds ratio [OR], 1.85; 95% CI, 1.08-3.16) and by 52.0% when the score of either parent was elevated (OR, 1.52; 95% CI, 1.11-2.06). Elevated scores of the father significantly increased the risk of ASD in the child (OR, 1.94; 95% CI, 1.38-2.71), but no association was seen with elevated scores of the mother. Elevated parent scores significantly increased child scores in controls, corresponding to an increase in 23 points (P < .001). These findings support the role of additive genetic influences in concentrating inherited ASD susceptibility in successive generations and the potential role of preferential mating, and suggest that typical variation in parental social functioning can produce clinically significant differences in offspring social traits.

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Collaboration types
Domestic collaboration
Web of Science research areas
Psychiatry
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