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Journal article
Pediatric Cardiovascular Multiscale Modeling using a Functional Mock-up Interface
Cardiovascular engineering and technology
06 Jan 2025
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
Purpose
Computational models of the cardiovascular system continue to increase in complexity. As more elements of the physiology are captured in multiscale models, there is a need to efficiently integrate subsystems. The objective of this study is to demonstrate the effectiveness of a coupling methodology, called functional mock-up interface (FMI), as applied to multiscale cardiovascular modeling.
Methods
The multiscale model is composed of two subsystems: a computational fluid dynamics (CFD) model coupled to a lumped parameter model (LPM). The LPM is packaged using the FMI standard and imported into the CFD subsystem using an FMI co-simulation architecture. The functionality of an FMI coupling was demonstrated in a univentricular parallel circulation by means of compatible tools, including ANSYS CFX and Python. Predicted pressures and flows were evaluated in comparison with clinical data and a previously developed computational model.
Results
The two models exchanged pressure and flow data between their boundaries at each timestep, demonstrating sufficient inter-subsystem communication. The models recreated pressures and flows from clinical measurements and a patient-specific model previously published.
Conclusion
FMI integrated with ANSYS CFX is an effective approach for interfacing cardiovascular multiscale models as demonstrated by the presented univentricular circulatory model. FMI offers a modular approach towards tool integration and is an advantageous strategy for modeling complex systems.
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Details
- Title
- Pediatric Cardiovascular Multiscale Modeling using a Functional Mock-up Interface
- Creators
- Ellen Elizabeth Garven (Corresponding Author) - Drexel University, School of Biomedical Engineering, Science, and Health SystemsEthan KungRandy M Stevens - Drexel University, PediatricsAmy Throckmorton - Drexel University, School of Biomedical Engineering, Science, and Health Systems
- Publication Details
- Cardiovascular engineering and technology
- Publisher
- Springer Nature
- Number of pages
- 9
- Grant note
- Drexel University's "Research and Engineering for Pediatrics by Interdisciplinary Collaboration Leveraging Education and Partnerships for Pediatric Healthcare" (R-EPIC LEAP for Pediatric Healthcare) from the U.S. Department of Education's GAANN Program
Funding was provided by Drexel University's "Research and Engineering for Pediatrics by Interdisciplinary Collaboration Leveraging Education and Partnerships for Pediatric Healthcare" (R-EPIC LEAP for Pediatric Healthcare) from the U.S. Department of Education's GAANN Program (Fellow: Ellen Garven).
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:001390294200001
- Scopus ID
- 2-s2.0-105001091593
- Other Identifier
- 991022008295404721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Engineering, Biomedical