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Percent Emphysema and Daily Motor Activity Levels in the General Population: Multi-Ethnic Study of Atherosclerosis
Journal article   Open access   Peer reviewed

Percent Emphysema and Daily Motor Activity Levels in the General Population: Multi-Ethnic Study of Atherosclerosis

Christian M Lo Cascio, Mirja Quante, Eric A Hoffman, Alain G Bertoni, Carrie P Aaron, Joseph E Schwartz, Mark V Avdalovic, Vincent S Fan, Gina S Lovasi, Steven M Kawut, …
Chest, v 151(5), pp 1039-1050
May 2017
DOI: https://doi.org/10.1016/j.chest.2016.11.033
PMID: 27940190
Featured in Collection :   UN Sustainable Development Goals @ Drexel
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https://doi.org/10.1016/j.chest.2016.11.033View
Published, Version of Record (VoR)Open Access (License Unspecified),  Open

Abstract

Actigraphy Aged Cohort Studies Coronary Artery Disease - epidemiology Ethnic Groups Exercise Female Forced Expiratory Volume Humans Linear Models Lung - diagnostic imaging Male Middle Aged Multivariate Analysis Prospective Studies Pulmonary Disease, Chronic Obstructive - diagnostic imaging Pulmonary Disease, Chronic Obstructive - epidemiology Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary Emphysema - diagnostic imaging Pulmonary Emphysema - epidemiology Pulmonary Emphysema - physiopathology Severity of Illness Index Smoking - epidemiology Stroke Volume Surveys and Questionnaires Tomography, X-Ray Computed United States - epidemiology Vascular Calcification - epidemiology Ventricular Dysfunction, Left - epidemiology Vital Capacity Walk Test
COPD is associated with reduced physical capacity. However, it is unclear whether pulmonary emphysema, which can occur without COPD, is associated with reduced physical activity in daily life, particularly among people without COPD and never smokers. We hypothesized that greater percentage of emphysema-like lung on CT scan is associated with reduced physical activity assessed by actigraphy and self-report. The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled participants free of clinical cardiovascular disease from the general population. Percent emphysema was defined as percentage of voxels < -950 Hounsfield units on full-lung CT scans. Physical activity was measured by wrist actigraphy over 7 days and a questionnaire. Multivariable linear regression was used to adjust for age, sex, race/ethnicity, height, weight, education, smoking, pack-years, and lung function. Among 1,435 participants with actigraphy and lung measures, 47% had never smoked, and 8% had COPD. Percent emphysema was associated with lower activity levels on actigraphy (P = .001), corresponding to 1.5 hour less per week of moderately paced walking for the average participant in quintile 2 vs 4 of percent emphysema. This association was significant among participants without COPD (P = .004) and among ever (P = .01) and never smokers (P = .03). It was also independent of coronary artery calcium and left ventricular ejection fraction. There was no evidence that percent emphysema was associated with self-reported activity levels. Percent emphysema was associated with decreased physical activity in daily life objectively assessed by actigraphy in the general population, among participants without COPD, and nonsmokers.

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Critical Care Medicine
Respiratory System
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