Journal article
Phenylephrine induces delayed cardioprotection against necrosis without amelioration of stunning
The Annals of thoracic surgery, v 68(4), pp 1219-1224
01 Oct 1999
PMID: 10543482
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background. α-Adrenergic stimulation induces protection in reperfused ischemic (I/R) myocardium 24 hours later. We tested the hypothesis that phenylephrine improves dysfunction after global I/R by limiting cell death not stunning.
Methods. Rabbits were pretreated with either phenylephrine or vehicle. Twenty-four hours later, isolated hearts underwent either 45 (infarction protocol) or 20 minutes (stunning protocol) of global ischemia before 2 hours of reperfusion (n = 6 per group). Cell death was determined by triphenyl tetrazolium chloride staining (infarction) and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) (apoptosis).
Results. Compared with vehicle, phenylephrine pretreatment improved post-I/R-developed pressures in hearts after infarction (53.2 ± 4.0 vs 35.8 ± 4.1 mm Hg,
p = 0.01) but not stunning protocol (64.3 ± 8.9 vs 57.7 ± 6.2 mm Hg,
p = NS). The improved developed pressure was due to better diastolic recovery. Systolic pressures were similar between groups. Phenylephrine markedly decreased infarction (9.0 ± 1.9% vs 40.8 ± 1.8% for vehicle,
p < 0.001) and TUNEL-positive staining. Stunned hearts of either group had less than 3% infarction and no apoptosis.
Conclusions. Phenylephrine pretreatment 24 hours before global I/R improves function by limiting infarction but not stunning.
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Details
- Title
- Phenylephrine induces delayed cardioprotection against necrosis without amelioration of stunning
- Creators
- Kourosh Baghelai - Virginia Commonwealth University Medical CenterLaura J Graham - Virginia Commonwealth UniversityAndrew S Wechsler - Virginia Commonwealth University Medical CenterEmma R Jakoi - Virginia Commonwealth University Medical Center
- Publication Details
- The Annals of thoracic surgery, v 68(4), pp 1219-1224
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; [Retired Faculty]
- Web of Science ID
- WOS:000083265800025
- Scopus ID
- 2-s2.0-0032696572
- Other Identifier
- 991020705329404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Respiratory System
- Surgery