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Phosphatidylcholine bilayers: Subtransitions in pure and in mixed lipids
Journal article   Peer reviewed

Phosphatidylcholine bilayers: Subtransitions in pure and in mixed lipids

Leonard Finegold and Michael A. Singer
Chemistry and physics of lipids, v 35(3)
1984
PMID: 6488416

Abstract

differential scanning calorimetry diheptadecanoylphosphatidylcholine liposomes (mixtures) subtransition
Aqueous dispersions of C14, C16, C17 and C18 phosphatidylcholines (PC, where Cn denotes di-acyl of n carbons per chain), and mixtures of C14/C16PC and C16/C17PC were prepared and their thermal properties studied by differential scanning calorimetry (d.s.c.) after sample storage at 2–6°C for up to 22 days. C16PC and C18PC display substransitions at 22°C and 29°C, respectively, as previously reported by Chen et al. (Proc. Natl. Acad. Sci. U.S.A. 77 (1980) 5060–5063). C17PC shows two subtransitions at 21°C and 26°C, respectively, which are independent of each other. Although C16PC and C17PC individually develop subtransitions, an equimolar mixture does not. However, mixtures of C14/C16PC containing 10 or more mol% of C14PC do display a subtransition. These results underscore the primary dependence of subtransition formation in phosphatidylcholine dispersions on acyl chain structure.

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Biochemistry & Molecular Biology
Biophysics
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