Journal article
Pneumatically-driven external pressure applicator to augment Fontan hemodynamics: preliminary findings
Translational pediatrics, v 2(4)
01 Oct 2013
PMCID: PMC4729077
PMID: 26835310
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: This study investigated the application of circumferentially applied, external pressure to the lower extremities as a preventative measure and long-term clinical treatment strategy for Fontan patients.
Objective: We hypothesized that the application of circumferential pressure to the lower limbs will augment venous return and thus cardiac output.
Methods: Two patients (an extra-cardiac and intra-atrial Fontan) were evaluated. Both trials were conducted during a routine cardiac catheterization. The aortic and inferior vena cava (IVC) pressures were recorded. We applied three different external pressures to the lower limbs based on the patient's diastolic pressure. Each pressure was applied with a one-minute rapid inflate/deflate period for a total of five cycles and a rest period between pressure intervals.
Results: Patient 1 (age 37, female) demonstrated pressure rises of 10-15 mmHg in both the aortic and IVC pressures. Patient 2 (age 24, male) had undetectable pressure rise during the first pressure cycles and notable pressures rise of approximately 8-12 mmHg during the third cycle.
Conclusions: External pressure application redistributes blood volume or cardiac output as a result of impedance in the lower extremities, enhancing venous pressure and return. Our findings strongly suggest an acute benefit from the implementation of external mechanical compression of the lower vasculature to increase cardiac output in Fontan patients.
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Details
- Title
- Pneumatically-driven external pressure applicator to augment Fontan hemodynamics: preliminary findings
- Creators
- Amy L. Throckmorton - Drexel UniversitySonya S. Bhavsar - Virginia Commonwealth UniversitySteven G. Chopski - Virginia Commonwealth UniversityWilliam B. Moskowitz - Children's Hospital of Richmond at VCU
- Publication Details
- Translational pediatrics, v 2(4)
- Publisher
- Ame Publ Co
- Number of pages
- 6
- Grant note
- U.S. Department of Education GAANN Interdisciplinary Graduate Engineering Education and Research (I-GEEAR) fellowship
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000218870000004
- Other Identifier
- 991019168738304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics