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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Pregnancy complications and obstetric suboptimality in association with autism spectrum disorders in children of the Nurses' Health Study II
Autism research, v 5(1), pp 21-30
Feb 2012
PMID: 21972225
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The authors examined pregnancy and obstetric complications in association with autism spectrum disorders (ASD) in children of participants from the Nurses' Health Study II, a prospective national cohort with information collected through biennial mailed questionnaires since 1989. Logistic regression was used to obtain crude and adjusted odds ratios for ASD, and by diagnostic subgroup. Seven hundred and ninety-three cases were reported among 66,445 pregnancies. Pregnancy complications and obstetric suboptimality factors were assessed by maternal report of occurrence in first birth and, in secondary analyses, in any birth. Complications and a suboptimality score were significantly associated with having a child with ASD (OR 1.49, 95% CI 1.26, 1.77, P<0.0001 for pregnancy complications in first birth and 2.76, 95% CI 2.04, 3.74, P<0.0001 comparing individuals with four or more obstetric suboptimality factors in first birth to those with none; results similar when assessed in any birth). In particular, gestational diabetes was associated with a significantly increased risk of ASD in results of primary and sensitivity analyses (OR in primary analysis = 1.76, 95% CI 1.34, 2.32, P<0.0001); suboptimal parity and suboptimal age-at-first-birth were also individual factors associated with ASD. Associations were similar by diagnostic subgroup, suggesting autism, Asperger syndrome, and other Pervasive Developmental Disorders are all associated with pregnancy complications. Consistent with previous research, the general class of pregnancy complications was associated with ASD as a whole. Additional work will be required to more fully assess the role of gestational diabetes.
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Details
- Title
- Pregnancy complications and obstetric suboptimality in association with autism spectrum disorders in children of the Nurses' Health Study II
- Creators
- Kristen Lyall - Harvard UniversityDavid L Pauls - Massachusetts General HospitalDonna Spiegelman - Harvard UniversityAlberto Ascherio - Brigham and Women's HospitalSusan L Santangelo - Massachusetts General Hospital
- Publication Details
- Autism research, v 5(1), pp 21-30
- Publisher
- Wiley
- Grant note
- R01 CA050385 / NCI NIH HHS AS1788 / Autism Speaks R01 CA050385-23 / NCI NIH HHS R01-CA50385 / NCI NIH HHS AS2210 / Autism Speaks
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000300871400004
- Scopus ID
- 2-s2.0-84857550472
- Other Identifier
- 991020099054704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Behavioral Sciences
- Psychology, Developmental