Journal article
Prenatal Maternal Serum Concentrations of Per- and Polyfluoroalkyl Substances in Association with Autism Spectrum Disorder and Intellectual Disability
Environmental health perspectives, v 126(1), pp 017001-017001
01 Jan 2018
PMID: 29298162
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUND: Emerging work has examined neurodevelopmental outcomes following prenatal exposure to per- and polyfluoroalkyl substances (PFAS), but few studies have assessed associations with autism spectrum disorder (ASD).
OBJECTIVES: Our objective was to estimate associations of maternal prenatal PEAS concentrations with ASD and intellectual disability (ID) in children.
METHODS: Participants were from a population-based nested case control study of children born from 2000 to 2003 in southern California, including children diagnosed with ASD = 553), ID without autism (n= 189), and general population (GP) controls (n =433), Concentrations of eight PFAS from stored maternal sera collected at 15-19 wk gestational age were quantified and compared among study groups. We used logistic regression to obtain adjusted odds ratios for the association between prenatal PEAS concentrations (parameterized continuously and as quartiles) and ASD versus GP controls, and separately for ID versus GP controls.
RESULTS: Geometric mean concentrations of most PEAS were lower in ASD and ID groups relative to GP controls. ASD was not significantly associated with prenatal concentrations of most PFAS, though significant inverse associations were found for perfluorooctanoate (PFOA) and perfluorooclane sulfonate (PFOS) [adjusted ORs for the highest vs. lowest quartiles 0.62 (95% CI: 0.41, 0.93) and 0.64 (95% CI: 0.43, 0.97), respectively]. Results for ID were similar.
CONCLUSIONS: Results from this large case control study with prospectively collected prenatal measurements do not support the hypothesis that prenatal exposure to PEAS is positively associated with ASD or ID.
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Details
- Title
- Prenatal Maternal Serum Concentrations of Per- and Polyfluoroalkyl Substances in Association with Autism Spectrum Disorder and Intellectual Disability
- Creators
- Kristen Lyall - Drexel UniversityVincent M. Yau - Kaiser PermanenteRobin Hansen - University of California, DavisMartin Kharrazi - California Department of Public HealthCathleen K. Yoshida - Kaiser PermanenteAntonia M. Calafat - National Center for Environmental Health, Centers for Disease Control and Prevention , Atlanta, Georgia, USA.Gayle Windham - California Department of Public HealthLisa A. Croen - Kaiser Permanente
- Publication Details
- Environmental health perspectives, v 126(1), pp 017001-017001
- Publisher
- Us Dept Health Human Sciences Public Health Science
- Number of pages
- 9
- Grant note
- R01ES016669 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) R01-ES016669 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000424212100007
- Scopus ID
- 2-s2.0-85041381080
- Other Identifier
- 991020100053904721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology