Journal article
Prepregnancy BMI, gestational weight gain, and susceptibility to autism‐related traits: the EARLI and HOME studies
Obesity (Silver Spring, Md.), v 31(5), pp 1415-1424
May 2023
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective : Excessive gestational weight gain (GWG) has been associated with autism spectrum disorder (ASD). This study sought to examine whether familial susceptibility for autism, intensity of ASD‐related behaviors, or prepregnancy BMI influences the association of GWG with ASD‐related behaviors.
Methods : Using data from the Early Autism Risk Longitudinal Investigation (EARLI) study (n = 136), a familial enriched cohort of mothers who had a previous child with ASD, and the Health Outcomes and Measures of the Environment (HOME) study (n = 253), a general population cohort, gestational age and prepregnancy BMI category‐specific GWG z scores were calculated. Caregivers completed the Social Responsiveness Scale (SRS) to assess the presence and severity of ASD‐related traits in children aged 3 to 8 years. Using quantile regression, the association between GWG z scores and ASD‐related behaviors in children was estimated.
Results : In HOME, among mothers who had overweight or obesity prepregnancy BMI values, GWG z scores and SRS scores were positively associated in children with more ASD‐related traits (higher SRS scores), but not in children with fewer ASD‐related traits. Similar patterns were observed in EARLI among mothers with prepregnancy obesity.
Conclusions : GWG may be associated with autism‐related behaviors among children who have a greater predisposition to these behaviors and who have mothers with prepregnancy overweight or obesity.
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Details
- Title
- Prepregnancy BMI, gestational weight gain, and susceptibility to autism‐related traits: the EARLI and HOME studies
- Creators
- Marisa A. Patti - Brown UniversityLisa A. Croen - Kaiser PermanenteAimin Chen - University of PennsylvaniaM. Daniele Fallin - Johns Hopkins UniversityJane Khoury - Cincinnati Children's Hospital Medical CenterKristen Lyall - Drexel UniversityCraig Newschaffer - Drexel UniversityIrva Hertz-Picciotto - University of California, DavisRebecca J. Schmidt - University of California, DavisKimberly Yolton - University of Cincinnati Medical CenterJoseph M. Braun - Brown University
- Publication Details
- Obesity (Silver Spring, Md.), v 31(5), pp 1415-1424
- Publisher
- Wiley
- Number of pages
- 10
- Grant note
- National Institutes of Health (R01 ES026903; R01 ES016443; R01 ES024381; R01 ES020349; P01 ES011261; R01 ES014575; R01 ES020349)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000983061200026
- Scopus ID
- 2-s2.0-85153740107
- Other Identifier
- 991020443016104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Nutrition & Dietetics