Journal article
Preservation of Auditory Brainstem Response Thresholds After Cochleostomy and Titanium Microactuator Implantation in the Lateral Wall of Cat Scala Tympani
Otology & neurotology, v 35(4), pp 730-738
Apr 2014
PMID: 24622027
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hypothesis
The safety of implanting a titanium microactuator into the lateral wall of cat scala tympani was assessed by comparing preoperative and postoperative auditory brainstem response (ABR) thresholds for 1 to 3 months.
Background
The safety of directly stimulating cochlear perilymph with an implantable hearing system requires maintaining preoperative hearing levels. This cat study is an essential step in the development of the next generation of fully implantable hearing devices for humans.
Methods
Following GLP surgical standards, a 1-mm cochleostomy was drilled into the lateral wall of the scala tympani, and a nonfunctioning titanium anchor/microactuator assembly was inserted in 8 cats. The scala media was damaged in the 1 cat. ABR thresholds with click and 4- and 8-kHz stimuli were measured preoperatively and compared with postoperative thresholds at 1, 2, and 3 months. Nonimplanted ear thresholds were also measured to establish statistical significance for threshold shifts (>28.4 dB). Two audiologists independently interpreted thresholds.
Results
Postoperatively, 7 cats implanted in the scala tympani demonstrated no significant ABR threshold shift for click stimulus; one shifted ABR thresholds to 4- and 8-kHz stimuli. The eighth cat, with surgical damage to the scala media, maintained stable click threshold but had a significant shift to 4- and 8-kHz stimuli.
Conclusion
This cat study provides no evidence of worsening hearing thresholds after fenestration of the scala tympani and insertion of a titanium anchor/microactuator, provided there is no surgical trauma to the scala media and the implanted device is securely anchored in the cochleostomy. These 2 issues have been resolved in the development of a fully implantable hearing system for humans. The long-term hearing stability (combined with histologic studies) reaffirm that the microactuator is well tolerated by the cat cochlea.
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Details
- Title
- Preservation of Auditory Brainstem Response Thresholds After Cochleostomy and Titanium Microactuator Implantation in the Lateral Wall of Cat Scala Tympani
- Creators
- S. George Lesinski - Cincinnati Children's Hospital Medical CenterJessica Prewitt - Queen City ENT Associates Cincinnati, Cincinnati, OH USAVictor Bray - Salus University (United States, Elkins Park)Radhika Aravamudhan - Salus University (United States, Elkins Park)Oscar A. Bermeo Blanco - Mécanique et Engrenage Moderne (France)Brenda L. Farmer-Fedor - OtoKinetics Inc, Salt Lake City, UT USAJonette A. Ward - Cincinnati Children's Hospital Medical Center
- Publication Details
- Otology & neurotology, v 35(4), pp 730-738
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 9
- Grant note
- OtoKinetics Inc.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Audiology - 4 Year
- Web of Science ID
- WOS:000333390700032
- Scopus ID
- 2-s2.0-84896902094
- Other Identifier
- 991022202856704721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Otorhinolaryngology