Journal article
Pressure-Flow Experimental Performance of New Intravascular Blood Pump Designs for Fontan Patients
Artificial organs, v 40(3)
01 Mar 2016
PMID: 26333131
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
An intravascular axial flow pump is being developed as a mechanical cavopulmonary assist device for adolescent and adult patients with dysfunctional Fontan physiology. Coupling computational modeling with experimental evaluation of prototypic designs, this study examined the hydraulic performance of 11 impeller prototypes with blade stagger or twist angles varying from 100 to 600 degrees. A refined range of twisted blade angles between 300 and 400 degrees with 20-degree increments was then selected, and four additional geometries were constructed and hydraulically evaluated. The prototypes met performance expectations and produced 3-31mmHg for flow rates of 1-5L/min for 6000-8000rpm. A regression analysis was completed with all characteristic coefficients contributing significantly (P<0.0001). This analysis revealed that the impeller with 400 degrees of blade twist outperformed the other designs. The findings of the numerical model for 300-degree twisted case and the experimental results deviated within approximately 20%. In an effort to simplify the impeller geometry, this work advanced the design of this intravascular cavopulmonary assist device closer to preclinical animal testing.
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Details
- Title
- Pressure-Flow Experimental Performance of New Intravascular Blood Pump Designs for Fontan Patients
- Creators
- Steven G. Chopski - Drexel UniversityCarson S. Fox - Drexel UniversityMichelle L. Riddle - Drexel UniversityKelli L. McKenna - Drexel UniversityJay P. Patel - Drexel UniversityJohn T. Rozolis - Drexel UniversityAmy L. Throckmorton - Drexel University
- Publication Details
- Artificial organs, v 40(3)
- Publisher
- Wiley
- Number of pages
- 10
- Grant note
- 15POST21130007 / American Heart Association 250596 / Philadelphia-TriUniversity Consortium
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000372336800006
- Scopus ID
- 2-s2.0-84959360057
- Other Identifier
- 991019168623204721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical
- Transplantation