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Journal article
Pseudobulbar Affect Presenting as Hypomania
Curēus (Palo Alto, CA), v 12(3), pe7308
18 Mar 2020
PMID: 32313749
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Pseudobulbar affect (PBA) is a behavioral syndrome associated with various neurological conditions that typically manifests as uncontrollable laughing or crying. PBA can significantly impact the quality of life of patients affected as these spells can be inappropriate to the social setting or incompatible with the patient's emotional state. The underlying mechanism of PBA appears to be associated with disinhibition in neuronal pathways involving dopamine, serotonin, and glutamate, but the exact mechanism remains unclear. One hypothesis for the pathology of PBA is that it is the result of disruption of the corticopontine-cerebellar circuits, impairing cerebellar modulation of affect, and leading to uncontrolled emotional lability. Stroke, and other neurological disorders, interrupt these neuronal circuits causing disinhibition of the voluntary control of emotional expression. It is extremely important to recognize and appropriately diagnose the condition. We present a case report of an 85-year-old female patient who presented with a thalamic stroke, and she subsequently developed hypomania with symptoms of decreased need for sleep, mood lability, pressured speech, and religious preoccupation. This case discusses a unique presentation of PBA with hypomania.
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Details
- Title
- Pseudobulbar Affect Presenting as Hypomania
- Creators
- Eduardo D. Espiridion - Reading HospitalCassandra Mitchell - Drexel UniversityShreeja Kadakia - Drexel University
- Publication Details
- Curēus (Palo Alto, CA), v 12(3), pe7308
- Publisher
- Cureus Inc
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry
- Web of Science ID
- WOS:000520024400007
- Other Identifier
- 991019168174504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, General & Internal