Files and links (1)
Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Psychiatric comorbidities in epilepsy: population co-occurrence, genetic correlations and causal effects
General psychiatry, v 37(1), e101201
Jan 2024
PMID: 39228867
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background
Psychiatric comorbidities are common in patients with epilepsy. Reasons for the co-occurrence of psychiatric conditions and epilepsy remain poorly understood.
Aim
We aimed to triangulate the relationship between epilepsy and psychiatric conditions to determine the extent and possible origins of these conditions.
Methods
Using nationwide Swedish health registries, we quantified the lifetime prevalence of psychiatric disorders in patients with epilepsy. We then used summary data from genome-wide association studies to investigate whether the identified observational associations could be attributed to a shared underlying genetic aetiology using cross-trait linkage disequilibrium score regression. Finally, we assessed the potential bidirectional relationships using two-sample Mendelian randomisation.
Results
In a cohort of 7 628 495 individuals, we found that almost half of the 94 435 individuals diagnosed with epilepsy were also diagnosed with a psychiatric condition in their lifetime (adjusted lifetime prevalence, 44.09%; 95% confidence interval (CI) 43.78% to 44.39%). We found evidence for a genetic correlation between epilepsy and some neurodevelopmental and psychiatric conditions. For example, we observed a genetic correlation between epilepsy and attention-deficit/hyperactivity disorder (r g =0.18, 95% CI 0.09 to 0.27, p<0.001)—a correlation that was more pronounced in focal epilepsy (r g =0.23, 95% CI 0.09 to 0.36, p<0.001). Findings from Mendelian randomisation using common genetic variants did not support bidirectional effects between epilepsy and neurodevelopmental or psychiatric conditions.
Conclusions
Psychiatric comorbidities are common in patients with epilepsy. Genetic correlations may partially explain some comorbidities; however, there is little evidence of a bidirectional relationship between the genetic liability of epilepsy and psychiatric conditions. These findings highlight the need to understand the role of environmental factors or rare genetic variations in the origins of psychiatric comorbidities in epilepsy.
Metrics
Details
- Title
- Psychiatric comorbidities in epilepsy: population co-occurrence, genetic correlations and causal effects
- Creators
- Viktor H Ahlqvist - University of BristolChristina Dardani - University of BristolPaul Madley-Dowd - University of BristolHarriet Forbes - University of BristolJessica Rast - Drexel UniversityCaichen Zhong - Drexel UniversityRenee M Gardner - Karolinska InstitutetChristina Dalman - Karolinska InstitutetKristen Lyall - Drexel UniversityCraig Newschaffer - Pennsylvania State UniversityTorbjörn Tomson - Karolinska InstitutetMichael Lundberg - Karolinska InstitutetDaniel Berglind - Karolinska InstitutetNeil M Davies - University College LondonBrian K Lee - Drexel UniversityCecilia Magnusson - Karolinska InstitutetDheeraj Rai - University of Bristol
- Publication Details
- General psychiatry, v 37(1), e101201
- Publisher
- British Medical Journal (BMJ)
- Grant note
- MC_UU_00011/1 / Medical Research Council (http://dx.doi.org/10.13039/501100000265) 295989 / Norges Forskningsråd (http://dx.doi.org/10.13039/501100005416) N/A / NIHR Biomedical Research Centre at the University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust 2020-00321 / Erik och Edith Fernströms Stiftelse för Medicinsk Forskning (http://dx.doi.org/10.13039/501100009747) RM21-0005 / Swedish Society for Medical Research 2020-00160; 2020-01172 / Karolinska Institutet 523-2010-1052 / Swedish Research Council 1R01NS107607-01A1 / National Institutes of Health (http://dx.doi.org/10.13039/100000002)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics; A.J. Drexel Autism Institute
- Web of Science ID
- WOS:001154946900001
- Scopus ID
- 2-s2.0-85183978763
- Other Identifier
- 991021838289404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Psychiatry