Journal article
Quantitative Evaluation of Blood Damage in a Centrifugal VAD by Computational Fluid Dynamics
Journal of fluids engineering, v 126(3), pp 410-418
01 May 2004
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study explores a quantitative evaluation of blood damage that occurs in a continuous flow left ventricular assist device (LVAD) due to fluid stress. Computational fluid dynamics (CFD) analysis is used to track the shear stress history of 388 particle streaklines. The accumulation of shear and exposure time is integrated along the streaklines to evaluate the levels of blood trauma. This analysis, which includes viscous and turbulent stresses, provides a statistical estimate of possible damage to cells flowing through the pump. Since experimental data for hemolysis levels in our LVAD are not available, in vitro normalized index of hemolysis values for clinically available ventricular assist devices were compared to our damage indices. This approach allowed for an order of magnitude comparison between our estimations and experimentally measured hemolysis levels, which resulted in a reasonable correlation. This work ultimately demonstrates that CFD is a convenient and effective approach to analyze the Lagrangian behavior of blood in a heart assist device.
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Details
- Title
- Quantitative Evaluation of Blood Damage in a Centrifugal VAD by Computational Fluid Dynamics
- Creators
- Xinwei Song - Mechanical and Aerospace Engineering Department, Virginia Artificial Heart Institute, University of Virginia, Charlottesville, VA USAAmy L Throckmorton - Biomedical Engineering Department, Virginia Artificial Heart Institute, University of Virginia, Charlottesville, VA USAHouston G Wood - Mechanical and Aerospace Engineering Department, Virginia Artificial Heart Institute, University of Virginia, Charlottesville, VA USAJames F Antaki - McGowan Center for Artificial Organ Development, University of Pittsburgh, Pittsburgh, PA USADon B Olsen - Utah Artificial Heart Institute, Salt Lake City, UT USA
- Publication Details
- Journal of fluids engineering, v 126(3), pp 410-418
- Publisher
- ASME
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000222806200013
- Scopus ID
- 2-s2.0-11144347532
- Other Identifier
- 991014877918604721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Mechanical