Journal article
REDUCED LEVELS OF NEURONAL-SPECIFIC MICROTUBULE-ASSOCIATED PROTEIN (MAP2) IN CANINE G(M1)-GANGLIOSIDOSIS
Neuroscience research communications, Vol.10(3), pp.155-161
01 May 1992
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Abstract
G(M1)-Gangliodosis is an inherited lysosomal storage disease characterized by deficient activity of beta-galactosidase. As a result the neurons in brain contain enlarged secondary lysosomes laden with lamellated membrane structures, and they develop abnormal morphology of their dendrites. Microtubule associated protein (MAP2) is a major structural component of the neuronal cytoskeleton which is preferentially associated with dendrites, and has been used as a marker for morphological changes and damage in dendrites induced by pathological conditions. We used six affected Portuguese Water Dogs as a canine model for G(M1)-Gangliodosis, and five age-matched controls. The lysosomal beta-galactosidase activity of all affected dogs was less than 5% of normal dogs. The relative levels of MAP2 in frontal lobe of affected dogs, determined by Western blot analysis, was 71.7 +/- -7.8 (mean +/- -SD) of control. There was no significant differences in the number of neurons between affected and aged-matched dogs. These findings indicate that in G(M1)-Gangliodosis there is a reduction in the levels of MAP2 which can serve as useful marker for the alteration in neuronal morphology.
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Details
- Title
- REDUCED LEVELS OF NEURONAL-SPECIFIC MICROTUBULE-ASSOCIATED PROTEIN (MAP2) IN CANINE G(M1)-GANGLIOSIDOSIS
- Creators
- FISCHER FischerJ Alroy
- Publication Details
- Neuroscience research communications, Vol.10(3), pp.155-161
- Publisher
- Wiley
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Identifiers
- 991019184312804721
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- Neurosciences