Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
RLS in middle aged women and attention deficit/hyperactivity disorder in their offspring
Sleep medicine, v 12(1), pp 89-91
01 Jan 2011
PMID: 20810309
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Previous studies have suggested that attention deficit/hyperactivity disorder (ADHD) and restless legs syndrome (RLS) could share some common genetic backgrounds, but the effect of these genetic components could be modest. To test this hypothesis, we conducted a large-scaled cross-sectional study to examine whether women with a child with ADHD had a higher risk of having RLS than women of unaffected children.
Methods: We included 65,554 women free of diabetes, arthritis, and pregnancy in the current analyses. Information on RLS was assessed using a set of standardized questions. Participants were considered to have RLS if they met four RLS diagnostic criteria recommended by the International RLS Study Group and had restless legs >= 5 times/month. Information on ADHD in offspring was collected via questionnaire.
Results: We observed a significant association between presence of ADHD in the offspring and risk of having RLS; the multivariate-adjusted OR for RLS was 1.27 (95% CI: 1.15, 1.41; P < 0.0001), after adjusting for age, body mass index, number of deliveries during life time and other covariates.
Conclusion: We found that mothers of children with ADHD had an increased risk of having RLS. Further studies are warranted to explore biological mechanisms underling this association. (C) 2010 Elsevier B.V. All rights reserved.
Metrics
Details
- Title
- RLS in middle aged women and attention deficit/hyperactivity disorder in their offspring
- Creators
- Xiang Gao - Brigham and Women's HospitalKristen Lyall - Harvard UniversityNatalia Palacios - Harvard UniversityArthur S. Walters - Vanderbilt UniversityAlberto Ascherio - Brigham and Women's Hospital
- Publication Details
- Sleep medicine, v 12(1), pp 89-91
- Publisher
- Elsevier
- Number of pages
- 3
- Grant note
- 1R01NS062879-01A2 / NIH/NINDS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01NS062879 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) A-14917 / US Army Medical Research and Material Command (USAMRMC); U.S. Army Medical Research & Materiel Command (USAMRMC)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000286865200017
- Scopus ID
- 2-s2.0-78650263376
- Other Identifier
- 991020099919504721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology