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Reactivity of gastroepiploic and internal mammary arteries
Journal article   Open access   Peer reviewed

Reactivity of gastroepiploic and internal mammary arteries

Rebecca J. Dignan, Thomas Yeh, Cornelius M. Dyke, K. Francis Lee, Harry A. Lutz, Mai Ding and Andrew S. Wechsler
The Journal of thoracic and cardiovascular surgery, v 103(1), pp 116-123
Jan 1992
DOI: https://doi.org/10.1016/S0022-5223(19)35073-1
url
https://doi.org/10.1016/S0022-5223(19)35073-1View
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Abstract

The gastroepiploic artery is an alternate conduit for coronary artery bypass grafting. To test the hypothesis that its vasoreactive properties are different from those of the internal mammary artery, we obtained gastroepiploic artery segments from human gastrectomy specimens. Trimmed internal mammary artery segments were obtained during coronary artery bypass. Ring segments were mounted on a strain gauge and stretched to optimum resting length (90 % of the internal circumference at 100 mm Hg). Potassium chloride, serotonin, and norepinephrine were chosen to simulate physiologic vasospasm induced by depolarization, platelet aggregation, or adrenergic stimulation, respectively. Contractions to potassium and a concentration-response curve to serotonin or norepinephrine were obtained. Sodium nitroprusside was used to assess relaxation. Gastroepiploic artery segments had stronger contractions to the depolarizing agent (potassium chloride), adrenergic stimulation (norepinephrine), and product of platelet aggregation (serotonin). The gastroepiploic and internal mammary arteries showed equal sensitivity, measured by concentration causing half-maximal contraction to norepinephrine and serotonin. There was no difference in relaxation to sodium nitroprusside. These data suggest that prevention of platelet-, adrenergic-, or potassium-induced contraction may be more important when the gastroepiploic artery is used as an alternate conduit for coronary artery bypass, reinforcing consideration of nitrovasodilators and platelet inhibitors in the perioperative interval. (J Thorac Cardiovasc Surg 1992;103:116—23)

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