Journal article
Reactivity to alpha agonists is heightened in immature porcine pulmonary arteries
The Annals of thoracic surgery, v 61(5), pp 1359-1362
01 May 1996
PMID: 8633941
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Pulmonary hypertension after cardiopulmonary bypass is a common problem in pediatric cardiac operations. This study tested the hypothesis that there is a difference between adult and immature pulmonary artery constrictor and dilator responses.
Reactivity of pulmonary artery ring segments from 22 mature (15 to 19 weeks) and 15 immature pigs (4 to 5 weeks) was tested in a vessel myograph. Potassium as s receptor-independent vasoconstrictor and phenylephrine as an α-receptor-mediated vasoconstrictor were used to assess smooth-muscle vasoconstriction. To assess endothelial cell function (nitric oxide production and secretion), we used increasing concentrations of bradykinin or acetylcholine. Sodium nitroprusside was used to produce maximum smooth-muscle relaxation at the end of each experiment.
The data demonstrated maturation-independent endothelium and smooth-muscle-mediated vasodilation. Pulmonary artery ring segments from immature pigs had significantly less KCI constriction compared with mature pigs (
p < 0.05). In contrast, pulmonary ring segments from immature pigs demonstrated enhanced
α-receptor-mediated constriction compared with mature pigs.
These data may explain perioperative pulmonary vasoconstriction in pediatric patients.
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Details
- Title
- Reactivity to alpha agonists is heightened in immature porcine pulmonary arteries
- Creators
- Margit KadletzRebecca J. DignanAndrew S. Wechsler
- Publication Details
- The Annals of thoracic surgery, v 61(5), pp 1359-1362
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; [Retired Faculty]
- Web of Science ID
- WOS:A1996UG90900017
- Scopus ID
- 2-s2.0-0029875183
- Other Identifier
- 991020705319604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Respiratory System
- Surgery