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Journal article
Recent Advances in HIV-1 Gag Inhibitor Design and Development
Molecules (Basel, Switzerland), v 25(7), p1687
01 Apr 2020
PMID: 32272714
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Acquired Immune Deficiency Syndrome (AIDS) treatment with combination antiretroviral therapy (cART) has improved the life quality of many patients since its implementation. However, resistance mutations and the accumulation of severe side effects associated with cART remain enormous challenges that need to be addressed with the continual design and redesign of anti-HIV drugs. In this review, we focus on the importance of the HIV-1 Gag polyprotein as the master coordinator of HIV-1 assembly and maturation and as an emerging drug target. Due to its multiple roles in the HIV-1 life cycle, the individual Gag domains are attractive but also challenging targets for inhibitor design. However, recent encouraging developments in targeting the Gag domains such as the capsid protein with highly potent and potentially long-acting inhibitors, as well as the exploration and successful targeting of challenging HIV-1 proteins such as the matrix protein, have demonstrated the therapeutic viability of this important protein. Such Gag-directed inhibitors have great potential for combating the AIDS pandemic and to be useful tools to dissect HIV-1 biology.
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Details
- Title
- Recent Advances in HIV-1 Gag Inhibitor Design and Development
- Creators
- Alexej Dick - Drexel UniversitySimon Cocklin - Drexel University
- Publication Details
- Molecules (Basel, Switzerland), v 25(7), p1687
- Publisher
- Mdpi
- Number of pages
- 25
- Grant note
- GM125396; R01AI150491 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000531833400212
- Scopus ID
- 2-s2.0-85083096817
- Other Identifier
- 991019168968904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary