Journal article
Regulation of retinal membrane guanylyl cyclase (RetGC) by negative calcium feedback and RD3 protein
Pflügers Archiv, v 473(9), pp 1393-1410
01 Sep 2021
PMID: 33537894
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This article presents a brief overview of the main biochemical and cellular processes involved in regulation of cyclic GMP production in photoreceptors. The main focus is on how the fluctuations of free calcium concentrations in photoreceptors between light and dark regulate the activity of retinal membrane guanylyl cyclase (RetGC) via calcium sensor proteins. The emphasis of the review is on the structure of RetGC and guanylyl cyclase activating proteins (GCAPs) in relation to their functional role in photoreceptors and congenital diseases of photoreceptors. In addition to that, the structure and function of retinal degeneration-3 protein (RD3), which regulates RetGC in a calcium-independent manner, is discussed in detail in connections with its role in photoreceptor biology and inherited retinal blindness.
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Details
- Title
- Regulation of retinal membrane guanylyl cyclase (RetGC) by negative calcium feedback and RD3 protein
- Creators
- Alexander M Dizhoor - Salus UniversityIgor V Peshenko - Salus University
- Publication Details
- Pflügers Archiv, v 473(9), pp 1393-1410
- Publisher
- Springer Nature
- Grant note
- R01 EY011522 / NEI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000614314700001
- Scopus ID
- 2-s2.0-85100412744
- Other Identifier
- 991022035112704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Physiology