Journal article
Retrograde flow in aortic isthmus in normal and fetal heart disease by principal component analysis and computational fluid dynamics
Echocardiography (Mount Kisco, N.Y.), v 39(2), pp 166-177
13 Jan 2022
PMID: 35026051
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives Reverse flow Retrograde flow (RF) of blood in the aortic isthmus can be observed in different types of fetal heart disease (FHD), including abnormalities in heart structure and function. This study sought to investigate the relationship between RF and blood flow parameters, and develop a computational fluid dynamics (CFD) model to understand the mechanisms underlying this observation. Material and methods A total of 281 fetuses (gestational age [GA] 26.6 +/-.3 weeks) with FHD and 2803 normal fetuses (GA: 26.1 +/-.1 weeks) by fetal echocardiography collected from May 2016 to December 2018. Principal component analysis (PCA) was performed to find the relationship and the CFD model reconstructed from 3D/4D spatio-temporal image correlation (STIC) images to simulate hemodynamics. Results There was a significant difference in the percentages of RF between the study (80/201 (39%)) and control (29/2803 (1%)) groups (p < 0.05). The RF occur when the aorta flow rate (left heart) is reduced to 60% by CFD stimulation. Pearson correlation analysis showed significant correlations between flow rate and wall shear stress(WSS) (r = .883, p = 0.047) variables at the AI. Conclusion Volumetric flow rate of AO or left heart was the main component of the cause of RF. The hemodynamics of the cardiovascular system have highly complex behavior hinge on the turbulent nature of circulating blood flow.
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Details
- Title
- Retrograde flow in aortic isthmus in normal and fetal heart disease by principal component analysis and computational fluid dynamics
- Creators
- Zhuo Chen - Beijing Anzhen HospitalHongkai Zhao - Beihang UniversityYing Zhao - Beijing Anzhen HospitalJiancheng Han - Beijing Anzhen HospitalXu Yang - Beijing Anzhen HospitalAmy Throckmorton - Drexel UniversityZhenglun Wei - University of Massachusetts LowellShuping Ge - Geisinger Medical CenterYihua He - Beijing Anzhen Hospital
- Publication Details
- Echocardiography (Mount Kisco, N.Y.), v 39(2), pp 166-177
- Publisher
- Wiley
- Number of pages
- 12
- Grant note
- Z181100001918008 / Beijing Municipal Science and Technology Commission, Beijing, China; Beijing Municipal Science & Technology Commission PXM2021_014226_000026 / Beijing Advanced Innovation Center for Big Data-based Precision Medicine, Capital Medical University, Beijing, China BZ0308 / Beijing Key Laboratory of Maternal-Fetal Medicine in Fetal Heart Disease, Beijing, China PXM2020_014226_000054 / Beijing Lab for Cardiovascular Precision Medicine, Beijing, China
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000742144600001
- Scopus ID
- 2-s2.0-85122734865
- Other Identifier
- 991019168026404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems