Journal article
Right Ventricular Sensitivity to Metabolic Injury During Cardiopulmonary Bypass
Archives of surgery (Chicago. 1960), v 121(3), pp 338-344
01 Mar 1986
PMID: 3947231
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Abstract
• To determine intrinsic right ventricular susceptibility to metabolic injury, we examined the effect of ischemia and reperfusion during cardiopulmonary bypass on right and left ventricular myocardial adenine nucleotide metabolism in the absence of ventricular work load as a determinant of energy production and utilization. Dogs were subjected either to 30 minutes of normothermic or hypothermic myocardial ischemia and reperfusion or to 60 minutes of potassium-arrested normothermic ischemia; serial ventricular biopsy specimens were assayed for adenosine triphosphate, adenosine diphosphate, adenosine monophosphate, nucleoside, and base content. In each group the depletion rates of right and left ventricular nucleotides with ischemia did not differ. Mitochondrial ability to rephosphorylate the nucleotide pool during and after ischemia also did not differ in the two ventricles, and there were no detectable differences in the catabolism of nucleotide precursors and loss of total purine content with reperfusion. These observations indicate that right ventricular myocardium is as equally sensitive to ischemic and reperfusion injury as left ventricular myocardium, and metabolic recovery from injury is equally prolonged.(Arch Surg 1986;121:338-344)
Metrics
Details
- Title
- Right Ventricular Sensitivity to Metabolic Injury During Cardiopulmonary Bypass
- Creators
- James J MorrisDavid P Hamm - Duke UniversityGary L Pellom - Duke UniversityAnwar Abd-Elfattah - Duke UniversityAndrew S Wechsler - Duke University
- Publication Details
- Archives of surgery (Chicago. 1960), v 121(3), pp 338-344
- Publisher
- American Medical Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; [Retired Faculty]
- Web of Science ID
- WOS:A1986A256800015
- Scopus ID
- 2-s2.0-0022650858
- Other Identifier
- 991020705320204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Surgery