Journal article
Secretion profile of human bone marrow stromal cells: Donor variability and response to inflammatory stimuli
Cytokine (Philadelphia, Pa.), v 50(3), pp 317-321
2010
PMID: 20185331
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mesenchymal stem cells (MSC) derived from bone marrow are ideal transplants for a variety of CNS disorders and appear to support recovery after injury by secreting therapeutic factors. There is considerable variability in the secretion profile of MSC derived from different donors and it is known that MSC secretion changes in response to inflammatory stimuli, but no comprehensive analysis has been performed to address these issues. Here we show that MSC from seven donors secrete chemokines and cytokines in variable ranges, with some factors showing high variability. Treatment of cultured MSC with pro-inflammatory cytokines or tissue extracts from injured spinal cord resulted in up-regulation of selected cytokines, whereas treatment with an anti-inflammatory cytokine had little effect, indicating that the secretion profile is tightly regulated by environmental challenges. Patterns of up-regulated cytokines were similar in MSC from different donors suggesting a comparable response to inflammatory stimuli.
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Details
- Title
- Secretion profile of human bone marrow stromal cells: Donor variability and response to inflammatory stimuli
- Creators
- Victoria ZhukarevaMaria ObrockaJohn D HouleItzhak FischerBirgit Neuhuber
- Publication Details
- Cytokine (Philadelphia, Pa.), v 50(3), pp 317-321
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000278411600016
- Scopus ID
- 2-s2.0-77952551255
- Other Identifier
- 991014878194704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Immunology