Journal article
Selective Adsorption of Trace Biomolecules by Amino Acid-Functionalized Ti 3 C 2 T x MXene
Small (Weinheim an der Bergstrasse, Germany), v 22(1), e09635
Jan 2026
PMID: 41259600
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Accurate detection and enrichment of trace-level biomolecules are essential for early disease diagnosis, environmental monitoring, and biotechnological research. However, conventional adsorbents often lack the sensitivity and selectivity required at ultralow analyte concentrations. Here, a systematic study is conducted on dopamine adsorption on amino-acid-surface-modified Ti
C
T
MXene nanosheets covalently grafted onto glass wool via silane linkers. Comprehensive characterization confirms the stability of the MXene lattice and successful functionalization. Continuous-flow columns packed with amino acid-MXene-coated glass wool are fabricated, enabling preconcentration and recovery from real samples. Adsorption follows the Langmuir isotherm and pseudo-second-order kinetics, indicative of chemisorption. Thermodynamic analysis (ΔG⁰ < 0, ΔH⁰ > 0, ΔS⁰ > 0) reveals a spontaneous, endothermic process accompanied by increased interfacial disorder. Among the tested modifiers, the cystine-modified MXene exhibits nearly complete uptake (10 ppm analyte) through synergistic effects of electrostatic attraction, hydrogen bonding, and thiol-catechol interactions. Under optimized conditions, >99% desorption is achieved using ultrasonic-assisted ethanol-acetic acid elution, with stable performance over ten adsorption-desorption cycles. Compared with activated carbon and silica gel, the amino acid-MXene adsorbents demonstrate markedly superior capacity, selectivity, and cycling stability, establishing a versatile platform for trace biomolecule capture and enrichment.
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Details
- Title
- Selective Adsorption of Trace Biomolecules by Amino Acid-Functionalized Ti 3 C 2 T x MXene
- Creators
- Hossein Vojoudi - Drexel University, Chemical and Biological EngineeringVahid Rad - Drexel University, Chemical and Biological EngineeringMasoud Soroush - Drexel University, Chemical and Biological Engineering
- Publication Details
- Small (Weinheim an der Bergstrasse, Germany), v 22(1), e09635
- Publisher
- WILEY-V C H VERLAG GMBH
- Number of pages
- 11
- Grant note
- CMMI-2134607 / Division of Civil, Mechanical and Manufacturing Innovation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:001618852900001
- Scopus ID
- 2-s2.0-105022509124
- Other Identifier
- 991022133620804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology
- Physics, Applied
- Physics, Condensed Matter