Journal article
Selective human serum albumin sensor from the screening of a fluorescent rosamine library
Journal of combinatorial chemistry, v 10(3), pp 376-380
May 2008
PMID: 18410151
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A fluorescent dye library approach for the development of a bioanalyte sensor was sought. The screening of a rosamine dye library against diverse macromolecules led to the discovery of a highly sensitive human serum albumin binder, G13, with approximately 36-fold fluorescence intensity change. G13 showed a highly selective response to HSA over other macromolecules including albumins from other species. The potential use of G13 for the detection of HSA in biofluids is described.
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Details
- Title
- Selective human serum albumin sensor from the screening of a fluorescent rosamine library
- Creators
- Young-Hoon Ahn - Department of Chemistry, New York University, New York, New York 10003, USAJun-Seok LeeYoung-Tae Chang
- Publication Details
- Journal of combinatorial chemistry, v 10(3), pp 376-380
- Publisher
- American Chemical Society; Washington, DC
- Grant note
- P20GM072029 / NIGMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Arts and Sciences; Chemistry; Drexel University
- Web of Science ID
- WOS:000255848700008
- Scopus ID
- 2-s2.0-45149090641
- Other Identifier
- 991020099050804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Applied
- Chemistry, Medicinal
- Chemistry, Multidisciplinary